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Human histone demethylase KDM6B can catalyse sequential oxidations.
Hopkinson RJ , Langley GW , Belle R , Walport LJ , Dunne K , Münzel M , Salah E , Kawamura A , Claridge TDW , Schofield CJ . Hopkinson RJ , et al. Among authors: munzel m. Chem Commun (Camb). 2018 Jul 12;54(57):7975-7978. doi: 10.1039/c8cc04057e. Chem Commun (Camb). 2018. PMID: 29961803 Free PMC article.
Is JmjC oxygenase catalysis limited to demethylation?
Hopkinson RJ, Walport LJ, Münzel M, Rose NR, Smart TJ, Kawamura A, Claridge TD, Schofield CJ. Hopkinson RJ, et al. Among authors: munzel m. Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7709-13. doi: 10.1002/anie.201303282. Epub 2013 Jun 20. Angew Chem Int Ed Engl. 2013. PMID: 23788451 Free PMC article.
Optimal translational termination requires C4 lysyl hydroxylation of eRF1.
Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Münzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Trudgian DC, Schödel J, McCullagh JS, Ge W, Kessler BM, Gilbert RJ, Frolova LY, Alkalaeva E, Ratcliffe PJ, Schofield CJ, Coleman ML. Feng T, et al. Among authors: munzel m. Mol Cell. 2014 Feb 20;53(4):645-54. doi: 10.1016/j.molcel.2013.12.028. Epub 2014 Jan 30. Mol Cell. 2014. PMID: 24486019 Free PMC article.
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Kawamura A, Münzel M, Kojima T, Yapp C, Bhushan B, Goto Y, Tumber A, Katoh T, King ON, Passioura T, Walport LJ, Hatch SB, Madden S, Müller S, Brennan PE, Chowdhury R, Hopkinson RJ, Suga H, Schofield CJ. Kawamura A, et al. Among authors: munzel m. Nat Commun. 2017 Apr 6;8:14773. doi: 10.1038/ncomms14773. Nat Commun. 2017. PMID: 28382930 Free PMC article.
YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase.
Sekirnik R, Wilkins SE, Bush J, Tarhonskaya H, Münzel M, Hussein A, Flashman E, Mohammed S, McDonough MA, Loenarz C, Schofield CJ. Sekirnik R, et al. Among authors: munzel m. Extremophiles. 2018 May;22(3):553-562. doi: 10.1007/s00792-018-1016-9. Epub 2018 Mar 9. Extremophiles. 2018. PMID: 29523972 Free PMC article.
Non-competitive cyclic peptides for targeting enzyme-substrate complexes.
McAllister TE, Yeh TL, Abboud MI, Leung IKH, Hookway ES, King ONF, Bhushan B, Williams ST, Hopkinson RJ, Münzel M, Loik ND, Chowdhury R, Oppermann U, Claridge TDW, Goto Y, Suga H, Schofield CJ, Kawamura A. McAllister TE, et al. Among authors: munzel m. Chem Sci. 2018 Apr 23;9(20):4569-4578. doi: 10.1039/c8sc00286j. eCollection 2018 May 28. Chem Sci. 2018. PMID: 29899950 Free PMC article.
Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.
Pfeffer I, Brewitz L, Krojer T, Jensen SA, Kochan GT, Kershaw NJ, Hewitson KS, McNeill LA, Kramer H, Münzel M, Hopkinson RJ, Oppermann U, Handford PA, McDonough MA, Schofield CJ. Pfeffer I, et al. Among authors: munzel m. Nat Commun. 2019 Oct 28;10(1):4910. doi: 10.1038/s41467-019-12711-7. Nat Commun. 2019. PMID: 31659163 Free PMC article.
An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor.
Bhushan B, Granata D, Kaas CS, Kasimova MA, Ren Q, Cramer CN, White MD, Hansen AMK, Fledelius C, Invernizzi G, Deibler K, Coleman OD, Zhao X, Qu X, Liu H, Zurmühl SS, Kodra JT, Kawamura A, Münzel M. Bhushan B, et al. Among authors: munzel m. Chem Sci. 2022 Feb 24;13(11):3256-3262. doi: 10.1039/d1sc06844j. eCollection 2022 Mar 16. Chem Sci. 2022. PMID: 35414877 Free PMC article.
Identification and engineering of potent cyclic peptides with selective or promiscuous binding through biochemical profiling and bioinformatic data analysis.
Smith TP, Bhushan B, Granata D, Kaas CS, Andersen B, Decoene KW, Ren Q, Liu H, Qu X, Yang Y, Pan J, Chen Q, Münzel M, Kawamura A. Smith TP, et al. Among authors: munzel m. RSC Chem Biol. 2023 Nov 14;5(1):12-18. doi: 10.1039/d3cb00168g. eCollection 2024 Jan 3. RSC Chem Biol. 2023. PMID: 38179194 Free PMC article.
79 results