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Fetal Hemoglobin Induction by Epigenetic Drugs.
Lavelle D, Engel JD, Saunthararajah Y. Lavelle D, et al. Among authors: engel jd. Semin Hematol. 2018 Apr;55(2):60-67. doi: 10.1053/j.seminhematol.2018.04.008. Epub 2018 Apr 22. Semin Hematol. 2018. PMID: 29958562 Free PMC article. Review.
Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes.
Campbell AD, Cui S, Shi L, Urbonya R, Mathias A, Bradley K, Bonsu KO, Douglas RR, Halford B, Schmidt L, Harro D, Giacherio D, Tanimoto K, Tanabe O, Engel JD. Campbell AD, et al. Among authors: engel jd. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18808-13. doi: 10.1073/pnas.1104964108. Epub 2011 Oct 31. Proc Natl Acad Sci U S A. 2011. PMID: 22042865 Free PMC article.
Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons.
Ibanez V, Vaitkus K, Rivers A, Molokie R, Cui S, Engel JD, DeSimone J, Lavelle D. Ibanez V, et al. Among authors: engel jd. Blood. 2017 Jan 12;129(2):260-263. doi: 10.1182/blood-2016-10-746727. Epub 2016 Dec 1. Blood. 2017. PMID: 27908882 Free PMC article. No abstract available.
Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.
Molokie R, Lavelle D, Gowhari M, Pacini M, Krauz L, Hassan J, Ibanez V, Ruiz MA, Ng KP, Woost P, Radivoyevitch T, Pacelli D, Fada S, Rump M, Hsieh M, Tisdale JF, Jacobberger J, Phelps M, Engel JD, Saraf S, Hsu LL, Gordeuk V, DeSimone J, Saunthararajah Y. Molokie R, et al. Among authors: engel jd. PLoS Med. 2017 Sep 7;14(9):e1002382. doi: 10.1371/journal.pmed.1002382. eCollection 2017 Sep. PLoS Med. 2017. PMID: 28880867 Free PMC article. Clinical Trial.
Small molecule therapeutics to treat the β-globinopathies.
Yu L, Myers G, Engel JD. Yu L, et al. Among authors: engel jd. Curr Opin Hematol. 2020 May;27(3):129-140. doi: 10.1097/MOH.0000000000000579. Curr Opin Hematol. 2020. PMID: 32167945 Free PMC article. Review.
304 results