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HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.
Elorza A, Soro-Arnáiz I, Meléndez-Rodríguez F, Rodríguez-Vaello V, Marsboom G, de Cárcer G, Acosta-Iborra B, Albacete-Albacete L, Ordóñez A, Serrano-Oviedo L, Giménez-Bachs JM, Vara-Vega A, Salinas A, Sánchez-Prieto R, Martín del Río R, Sánchez-Madrid F, Malumbres M, Landázuri MO, Aragonés J. Elorza A, et al. Mol Cell. 2012 Dec 14;48(5):681-91. doi: 10.1016/j.molcel.2012.09.017. Epub 2012 Oct 25. Mol Cell. 2012. PMID: 23103253 Free article.
p38MAPK and Chemotherapy: We Always Need to Hear Both Sides of the Story.
García-Cano J, Roche O, Cimas FJ, Pascual-Serra R, Ortega-Muelas M, Fernández-Aroca DM, Sánchez-Prieto R. García-Cano J, et al. Front Cell Dev Biol. 2016 Jun 30;4:69. doi: 10.3389/fcell.2016.00069. eCollection 2016. Front Cell Dev Biol. 2016. PMID: 27446920 Free PMC article. Review.
E1a is an exogenous in vivo tumour suppressor.
Cimas FJ, Callejas-Valera JL, García-Olmo DC, Hernández-Losa J, Melgar-Rojas P, Ruiz-Hidalgo MJ, Pascual-Serra R, Ortega-Muelas M, Roche O, Marcos P, Garcia-Gil E, Fernandez-Aroca DM, Ramón Y Cajal S, Gutkind JS, Sanchez-Prieto R. Cimas FJ, et al. Cancer Lett. 2017 Jul 28;399:74-81. doi: 10.1016/j.canlet.2017.04.010. Epub 2017 Apr 15. Cancer Lett. 2017. PMID: 28416454
Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion.
Serrano-Oviedo L, Ortega-Muelas M, García-Cano J, Valero ML, Cimas FJ, Pascual-Serra R, Fernandez-Aroca DM, Roche O, Ruiz-Hidalgo MJ, Belandia B, Giménez-Bachs JM, Salinas AS, Sanchez-Prieto R. Serrano-Oviedo L, et al. PLoS One. 2018 Jul 26;13(7):e0200878. doi: 10.1371/journal.pone.0200878. eCollection 2018. PLoS One. 2018. PMID: 30048489 Free PMC article.
HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.
Meléndez-Rodríguez F, Urrutia AA, Lorendeau D, Rinaldi G, Roche O, Böğürcü-Seidel N, Ortega Muelas M, Mesa-Ciller C, Turiel G, Bouthelier A, Hernansanz-Agustín P, Elorza A, Escasany E, Li QOY, Torres-Capelli M, Tello D, Fuertes E, Fraga E, Martínez-Ruiz A, Pérez B, Giménez-Bachs JM, Salinas-Sánchez AS, Acker T, Sánchez Prieto R, Fendt SM, De Bock K, Aragonés J. Meléndez-Rodríguez F, et al. Cell Rep. 2019 Feb 26;26(9):2257-2265.e4. doi: 10.1016/j.celrep.2019.01.106. Cell Rep. 2019. PMID: 30811976 Free article.
p38β and Cancer: The Beginning of the Road.
Roche O, Fernández-Aroca DM, Arconada-Luque E, García-Flores N, Mellor LF, Ruiz-Hidalgo MJ, Sánchez-Prieto R. Roche O, et al. Int J Mol Sci. 2020 Oct 12;21(20):7524. doi: 10.3390/ijms21207524. Int J Mol Sci. 2020. PMID: 33053909 Free PMC article. Review.
83 results