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Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation.
Held NM, Kuipers EN, van Weeghel M, van Klinken JB, Denis SW, Lombès M, Wanders RJ, Vaz FM, Rensen PCN, Verhoeven AJ, Boon MR, Houtkooper RH. Held NM, et al. Among authors: van weeghel m, van klinken jb. Sci Rep. 2018 Jun 22;8(1):9562. doi: 10.1038/s41598-018-27875-3. Sci Rep. 2018. PMID: 29934543 Free PMC article.
CD36 is important for adipocyte recruitment and affects lipolysis.
Vroegrijk IO, van Klinken JB, van Diepen JA, van den Berg SA, Febbraio M, Steinbusch LK, Glatz JF, Havekes LM, Voshol PJ, Rensen PC, van Dijk KW, van Harmelen V. Vroegrijk IO, et al. Among authors: van harmelen v, van diepen ja, van dijk kw, van klinken jb, van den berg sa. Obesity (Silver Spring). 2013 Oct;21(10):2037-45. doi: 10.1002/oby.20354. Epub 2013 May 29. Obesity (Silver Spring). 2013. PMID: 23512311 Free article.
Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake.
van den Berg SA, Heemskerk MM, Geerling JJ, van Klinken JB, Schaap FG, Bijland S, Berbée JF, van Harmelen VJ, Pronk AC, Schreurs M, Havekes LM, Rensen PC, van Dijk KW. van den Berg SA, et al. Among authors: van harmelen vj, van dijk kw, van klinken jb. FASEB J. 2013 Aug;27(8):3354-62. doi: 10.1096/fj.12-225367. Epub 2013 May 6. FASEB J. 2013. PMID: 23650188
Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B.
Heemskerk MM, van den Berg SA, Pronk AC, van Klinken JB, Boon MR, Havekes LM, Rensen PC, van Dijk KW, van Harmelen V. Heemskerk MM, et al. Among authors: van harmelen v, van dijk kw, van klinken jb, van den berg sa. Am J Physiol Endocrinol Metab. 2014 Apr 1;306(7):E808-13. doi: 10.1152/ajpendo.00641.2013. Epub 2014 Jan 28. Am J Physiol Endocrinol Metab. 2014. PMID: 24473440 Free PMC article.
Postprandial metabolite profiles associated with type 2 diabetes clearly stratify individuals with impaired fasting glucose.
Li-Gao R, de Mutsert R, Rensen PCN, van Klinken JB, Prehn C, Adamski J, van Hylckama Vlieg A, den Heijer M, le Cessie S, Rosendaal FR, Willems van Dijk K, Mook-Kanamori DO. Li-Gao R, et al. Among authors: van klinken jb, van hylckama vlieg a. Metabolomics. 2018;14(1):13. doi: 10.1007/s11306-017-1307-7. Epub 2017 Dec 12. Metabolomics. 2018. PMID: 29249917 Free PMC article.
The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men.
Nahon KJ, Janssen LGM, Sardjoe Mishre ASD, Bilsen MP, van der Eijk JA, Botani K, Overduin LA, Ruiz JR, Burakiewicz J, Dzyubachyk O, Webb AG, Kan HE, Berbée JFP, van Klinken JB, van Dijk KW, van Weeghel M, Vaz FM, Coskun T, Jazet IM, Kooijman S, Martinez-Tellez B, Boon MR, Rensen PCN. Nahon KJ, et al. Among authors: van weeghel m, van der eijk ja, van dijk kw, van klinken jb. Diabetes Obes Metab. 2020 Nov;22(11):2032-2044. doi: 10.1111/dom.14120. Epub 2020 Jul 29. Diabetes Obes Metab. 2020. PMID: 32558052 Free PMC article. Clinical Trial.
Genome-Wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in LIPC (Hepatic Lipase).
Ibi D, Noordam R, van Klinken JB, Li-Gao R, de Mutsert R, Trompet S, Christen T, Blauw LL, van Heemst D, Mook-Kanamori DO, Rosendaal FR, Jukema JW, Dollé MET, Rensen PCN, van Dijk KW. Ibi D, et al. Among authors: van heemst d, van dijk kw, van klinken jb. Circ Genom Precis Med. 2020 Aug;13(4):e002693. doi: 10.1161/CIRCGEN.119.002693. Epub 2020 Jun 30. Circ Genom Precis Med. 2020. PMID: 32603185
Angiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.
van Eenige R, In Het Panhuis W, Schönke M, Jouffe C, Devilee TH, Siebeler R, Streefland TCM, Sips HCM, Pronk ACM, Vorderman RHP, Mei H, van Klinken JB, van Weeghel M, Uhlenhaut NH, Kersten S, Rensen PCN, Kooijman S. van Eenige R, et al. Among authors: van weeghel m, van klinken jb. Mol Metab. 2022 Jun;60:101497. doi: 10.1016/j.molmet.2022.101497. Epub 2022 Apr 10. Mol Metab. 2022. PMID: 35413480 Free PMC article.
Alterations in ether lipid metabolism and the consequences for the mouse lipidome.
Lackner K, Sailer S, van Klinken JB, Wever E, Pras-Raves ML, Dane AD, Honsho M, Abe Y, Keller MA, Golderer G, Werner-Felmayer G, Fujiki Y, Vaz FM, Werner ER, Watschinger K. Lackner K, et al. Among authors: van klinken jb. Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Apr;1868(4):159285. doi: 10.1016/j.bbalip.2023.159285. Epub 2023 Jan 21. Biochim Biophys Acta Mol Cell Biol Lipids. 2023. PMID: 36690320 Free article.
Discovery of novel diagnostic biomarkers for Sjögren-Larsson syndrome by untargeted lipidomics.
Vaz FM, Staps P, van Klinken JB, van Lenthe H, Vervaart M, Wanders RJA, Pras-Raves ML, van Weeghel M, Salomons GS, Ferdinandusse S, Wevers RA, Willemsen MAAP. Vaz FM, et al. Among authors: van klinken jb. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Mar;1869(2):159447. doi: 10.1016/j.bbalip.2023.159447. Epub 2024 Jan 3. Biochim Biophys Acta Mol Cell Biol Lipids. 2024. PMID: 38181883 Free article.
64 results