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Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis.
Hoeke G, Wang Y, van Dam AD, Mol IM, Gart E, Klop HG, van den Berg SM, Pieterman EH, Princen HMG, Groen AK, Rensen PCN, Berbée JFP, Boon MR. Hoeke G, et al. Among authors: mol im. Atherosclerosis. 2017 Dec;267:116-126. doi: 10.1016/j.atherosclerosis.2017.10.030. Epub 2017 Oct 26. Atherosclerosis. 2017. PMID: 29121499
The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat.
Schilperoort M, van Dam AD, Hoeke G, Shabalina IG, Okolo A, Hanyaloglu AC, Dib LH, Mol IM, Caengprasath N, Chan YW, Damak S, Miller AR, Coskun T, Shimpukade B, Ulven T, Kooijman S, Rensen PC, Christian M. Schilperoort M, et al. Among authors: mol im. EMBO Mol Med. 2018 Mar;10(3):e8047. doi: 10.15252/emmm.201708047. EMBO Mol Med. 2018. PMID: 29343498 Free PMC article.
A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening.
van den Berg R, Kooijman S, Noordam R, Ramkisoensing A, Abreu-Vieira G, Tambyrajah LL, Dijk W, Ruppert P, Mol IM, Kramar B, Caputo R, Puig LS, de Ruiter EM, Kroon J, Hoekstra M, van der Sluis RJ, Meijer OC, Willems van Dijk K, van Kerkhof LWM, Christodoulides C, Karpe F, Gerhart-Hines Z, Kersten S, Meijer JH, Coomans CP, van Heemst D, Biermasz NR, Rensen PCN. van den Berg R, et al. Among authors: mol im. Cell Rep. 2018 Mar 27;22(13):3521-3533. doi: 10.1016/j.celrep.2018.03.004. Cell Rep. 2018. PMID: 29590620 Free article.
Selective Glucocorticoid Receptor Modulation Prevents and Reverses Nonalcoholic Fatty Liver Disease in Male Mice.
Koorneef LL, van den Heuvel JK, Kroon J, Boon MR, 't Hoen PAC, Hettne KM, van de Velde NM, Kolenbrander KB, Streefland TCM, Mol IM, Sips HCM, Kielbasa SM, Mei H, Belanoff JK, Pereira AM, Oosterveer MH, Hunt H, Rensen PCN, Meijer OC. Koorneef LL, et al. Among authors: mol im. Endocrinology. 2018 Dec 1;159(12):3925-3936. doi: 10.1210/en.2018-00671. Endocrinology. 2018. PMID: 30321321
A physiological glucocorticoid rhythm is an important regulator of brown adipose tissue function.
Kroon J, Schilperoort M, In Het Panhuis W, van den Berg R, van Doeselaar L, Verzijl CRC, van Trigt N, Mol IM, Sips HHCM, van den Heuvel JK, Koorneef LL, van der Sluis RJ, Fenzl A, Kiefer FW, Vettorazzi S, Tuckermann JP, Biermasz NR, Meijer OC, Rensen PCN, Kooijman S. Kroon J, et al. Among authors: mol im. Mol Metab. 2021 May;47:101179. doi: 10.1016/j.molmet.2021.101179. Epub 2021 Feb 3. Mol Metab. 2021. PMID: 33548499 Free PMC article.
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.
Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC. Berbée JF, et al. Among authors: mol im. Nat Commun. 2015 Mar 10;6:6356. doi: 10.1038/ncomms7356. Nat Commun. 2015. PMID: 25754609 Free PMC article.
Chronic infusion of taurolithocholate into the brain increases fat oxidation in mice.
Eggink HM, Tambyrajah LL, van den Berg R, Mol IM, van den Heuvel JK, Koehorst M, Groen AK, Boelen A, Kalsbeek A, Romijn JA, Rensen PCN, Kooijman S, Soeters MR. Eggink HM, et al. Among authors: mol im. J Endocrinol. 2018 Feb;236(2):85-97. doi: 10.1530/JOE-17-0503. Epub 2017 Dec 12. J Endocrinol. 2018. PMID: 29233934
31 results