Downward J - Search Results

1

AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons.

Soutar MPM, Kempthorne L, Miyakawa S, Annuario E, Melandri D, Harley J, O'Sullivan GA, Wray S, Hancock DC, Cookson MR, Downward J, Carlton M, Plun-Favreau H. Soutar MPM, et al. Among authors: downward j. Sci Rep. 2018 Jun 11;8(1):8855. doi: 10.1038/s41598-018-26949-6. Sci Rep. 2018. PMID: 29891871 Free PMC article.

2

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.

Marani M, Tenev T, Hancock D, Downward J, Lemoine NR. Marani M, et al. Among authors: downward j. Mol Cell Biol. 2002 Jun;22(11):3577-89. doi: 10.1128/MCB.22.11.3577-3589.2002. Mol Cell Biol. 2002. PMID: 11997495 Free PMC article.

3

c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner.

Iaccarino I, Hancock D, Evan G, Downward J. Iaccarino I, et al. Among authors: downward j. Cell Death Differ. 2003 May;10(5):599-608. doi: 10.1038/sj.cdd.4401211. Cell Death Differ. 2003. PMID: 12728258

4

Role of Bim in the survival pathway induced by Raf in epithelial cells.

Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR. Marani M, et al. Among authors: downward j. Oncogene. 2004 Apr 1;23(14):2431-41. doi: 10.1038/sj.onc.1207364. Oncogene. 2004. PMID: 14676826

5

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.

Strauss KM, Martins LM, Plun-Favreau H, Marx FP, Kautzmann S, Berg D, Gasser T, Wszolek Z, Müller T, Bornemann A, Wolburg H, Downward J, Riess O, Schulz JB, Krüger R. Strauss KM, et al. Among authors: downward j. Hum Mol Genet. 2005 Aug 1;14(15):2099-111. doi: 10.1093/hmg/ddi215. Epub 2005 Jun 16. Hum Mol Genet. 2005. PMID: 15961413

6

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.

Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC. Nicke B, et al. Among authors: downward j. Mol Cell. 2005 Dec 9;20(5):673-85. doi: 10.1016/j.molcel.2005.10.038. Mol Cell. 2005. PMID: 16337592 Free article.

7

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, Downward J. Plun-Favreau H, et al. Among authors: downward j. Nat Cell Biol. 2007 Nov;9(11):1243-52. doi: 10.1038/ncb1644. Epub 2007 Sep 30. Nat Cell Biol. 2007. PMID: 17906618

8

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.

Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, Downward J, Mansfield L, Jat P, Taylor J, Heales S, Duchen MR, Latchman D, Tabrizi SJ, Wood NW. Wood-Kaczmar A, et al. Among authors: downward j. PLoS One. 2008 Jun 18;3(6):e2455. doi: 10.1371/journal.pone.0002455. PLoS One. 2008. PMID: 18560593 Free PMC article.

9

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin.

Tain LS, Chowdhury RB, Tao RN, Plun-Favreau H, Moisoi N, Martins LM, Downward J, Whitworth AJ, Tapon N. Tain LS, et al. Among authors: downward j. Cell Death Differ. 2009 Aug;16(8):1118-25. doi: 10.1038/cdd.2009.23. Epub 2009 Mar 13. Cell Death Differ. 2009. PMID: 19282869 Free PMC article.

10

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.

Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, Klupsch K, Downward J, Latchman DS, Tabrizi SJ, Wood NW, Duchen MR, Abramov AY. Gandhi S, et al. Among authors: downward j. Mol Cell. 2009 Mar 13;33(5):627-38. doi: 10.1016/j.molcel.2009.02.013. Mol Cell. 2009. PMID: 19285945 Free PMC article.

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