Thøgersen H - Search Results

1

α-Helix or β-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.

Oddo A, Mortensen S, Thøgersen H, De Maria L, Hennen S, McGuire JN, Kofoed J, Linderoth L, Reedtz-Runge S. Oddo A, et al. Among authors: thogersen h. Biochemistry. 2018 Jul 17;57(28):4148-4154. doi: 10.1021/acs.biochem.8b00105. Epub 2018 Jun 21. Biochemistry. 2018. PMID: 29877701

2

Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain.

Runge S, Schimmer S, Oschmann J, Schiødt CB, Knudsen SM, Jeppesen CB, Madsen K, Lau J, Thøgersen H, Rudolph R. Runge S, et al. Among authors: thogersen h. Biochemistry. 2007 May 15;46(19):5830-40. doi: 10.1021/bi062309m. Epub 2007 Apr 20. Biochemistry. 2007. PMID: 17444618

3

High-resolution structure of an engineered biologically potent insulin monomer, B16 Tyr-->His, as determined by nuclear magnetic resonance spectroscopy.

Ludvigsen S, Roy M, Thøgersen H, Kaarsholm NC. Ludvigsen S, et al. Among authors: thogersen h. Biochemistry. 1994 Jul 5;33(26):7998-8006. doi: 10.1021/bi00192a003. Biochemistry. 1994. PMID: 8025104

4

Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.

Runge S, Thøgersen H, Madsen K, Lau J, Rudolph R. Runge S, et al. Among authors: thogersen h. J Biol Chem. 2008 Apr 25;283(17):11340-7. doi: 10.1074/jbc.M708740200. Epub 2008 Feb 20. J Biol Chem. 2008. PMID: 18287102 Free article.

5

Structure-activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: importance of fatty acid length, polarity, and bulkiness.

Madsen K, Knudsen LB, Agersoe H, Nielsen PF, Thøgersen H, Wilken M, Johansen NL. Madsen K, et al. Among authors: thogersen h. J Med Chem. 2007 Nov 29;50(24):6126-32. doi: 10.1021/jm070861j. Epub 2007 Nov 2. J Med Chem. 2007. PMID: 17975905

6

Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration.

Knudsen LB, Nielsen PF, Huusfeldt PO, Johansen NL, Madsen K, Pedersen FZ, Thøgersen H, Wilken M, Agersø H. Knudsen LB, et al. Among authors: thogersen h. J Med Chem. 2000 May 4;43(9):1664-9. doi: 10.1021/jm9909645. J Med Chem. 2000. PMID: 10794683

7

Engineering Xaa-Pro dipeptidyl aminopeptidase for specific cleavage of glucagon and glucagon-like peptide 1 from fusion proteins.

Vernet E, Pedersen MØ, Thøgersen H, Shaw AC. Vernet E, et al. Among authors: thogersen h. Protein Expr Purif. 2020 Jun;170:105590. doi: 10.1016/j.pep.2020.105590. Epub 2020 Jan 30. Protein Expr Purif. 2020. PMID: 32007557

8

Glucagon fibril polymorphism reflects differences in protofilament backbone structure.

Andersen CB, Hicks MR, Vetri V, Vandahl B, Rahbek-Nielsen H, Thøgersen H, Thøgersen IB, Enghild JJ, Serpell LC, Rischel C, Otzen DE. Andersen CB, et al. Among authors: thogersen ib, thogersen h. J Mol Biol. 2010 Apr 9;397(4):932-46. doi: 10.1016/j.jmb.2010.02.012. Epub 2010 Feb 12. J Mol Biol. 2010. PMID: 20156459

9

Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.

Sauerberg P, Olesen PH, Sheardown MJ, Rimvall K, Thøgersen H, Shannon HE, Sawyer BD, Ward JS, Bymaster FP, DeLapp NW, Calligaro DO, Swedberg MD. Sauerberg P, et al. Among authors: thogersen h. J Med Chem. 1998 Jan 1;41(1):109-16. doi: 10.1021/jm9705216. J Med Chem. 1998. PMID: 9438027

10

Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selective α-melanocyte-stimulating hormone (α-MSH) analogues.

Conde-Frieboes K, Thøgersen H, Lau JF, Sensfuss U, Hansen TK, Christensen L, Spetzler J, Olsen HB, Nilsson C, Raun K, Dahl K, Hansen BS, Wulff BS. Conde-Frieboes K, et al. Among authors: thogersen h. J Med Chem. 2012 Mar 8;55(5):1969-77. doi: 10.1021/jm201489a. Epub 2012 Feb 24. J Med Chem. 2012. PMID: 22335602

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