Schüler H - Search Results

1

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.

Favalli N, Biendl S, Hartmann M, Piazzi J, Sladojevich F, Gräslund S, Brown PJ, Näreoja K, Schüler H, Scheuermann J, Franzini R, Neri D. Favalli N, et al. Among authors: schuler h. ChemMedChem. 2018 Jul 6;13(13):1303-1307. doi: 10.1002/cmdc.201800193. Epub 2018 Jun 1. ChemMedChem. 2018. PMID: 29856130 Free PMC article.

2

Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library.

Samain F, Ekblad T, Mikutis G, Zhong N, Zimmermann M, Nauer A, Bajic D, Decurtins W, Scheuermann J, Brown PJ, Hall J, Gräslund S, Schüler H, Neri D, Franzini RM. Samain F, et al. Among authors: schuler h. J Med Chem. 2015 Jun 25;58(12):5143-9. doi: 10.1021/acs.jmedchem.5b00432. Epub 2015 Jun 10. J Med Chem. 2015. PMID: 26061013

3

Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library.

Franzini RM, Ekblad T, Zhong N, Wichert M, Decurtins W, Nauer A, Zimmermann M, Samain F, Scheuermann J, Brown PJ, Hall J, Gräslund S, Schüler H, Neri D. Franzini RM, et al. Among authors: schuler h. Angew Chem Int Ed Engl. 2015 Mar 23;54(13):3927-31. doi: 10.1002/anie.201410736. Epub 2015 Feb 3. Angew Chem Int Ed Engl. 2015. PMID: 25650139

4

A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD⁺-Dependent Enzymes.

Yuen LH, Dana S, Liu Y, Bloom SI, Thorsell AG, Neri D, Donato AJ, Kireev D, Schüler H, Franzini RM. Yuen LH, et al. Among authors: schuler h. J Am Chem Soc. 2019 Apr 3;141(13):5169-5181. doi: 10.1021/jacs.8b08039. Epub 2019 Mar 19. J Am Chem Soc. 2019. PMID: 30855951

5

Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.

Stenmark P, Kursula P, Flodin S, Gräslund S, Landry R, Nordlund P, Schüler H. Stenmark P, et al. Among authors: schuler h. J Biol Chem. 2007 Feb 2;282(5):3182-7. doi: 10.1074/jbc.M609838200. Epub 2006 Nov 29. J Biol Chem. 2007. PMID: 17138556 Free article.

6

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site.

Trésaugues L, Stenmark P, Schüler H, Flodin S, Welin M, Nyman T, Hammarström M, Moche M, Gräslund S, Nordlund P. Trésaugues L, et al. Among authors: schuler h. Proteins. 2008 Dec;73(4):1047-52. doi: 10.1002/prot.22198. Proteins. 2008. PMID: 18767156 No abstract available.

7

Correction to "A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD⁺-Dependent Enzymes".

Yuen LH, Dana S, Liu Y, Bloom SI, Thorsell AG, Neri D, Donato AJ, Kireev D, Schüler H, Franzini RM. Yuen LH, et al. Among authors: schuler h. J Am Chem Soc. 2021 Jul 28;143(29):11272-11273. doi: 10.1021/jacs.1c06352. Epub 2021 Jul 16. J Am Chem Soc. 2021. PMID: 34270900 No abstract available.

8

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.

Karlberg T, Hornyak P, Pinto AF, Milanova S, Ebrahimi M, Lindberg M, Püllen N, Nordström A, Löverli E, Caraballo R, Wong EV, Näreoja K, Thorsell AG, Elofsson M, De La Cruz EM, Björkegren C, Schüler H. Karlberg T, et al. Among authors: schuler h. Nat Commun. 2018 Sep 17;9(1):3785. doi: 10.1038/s41467-018-06194-1. Nat Commun. 2018. PMID: 30224724 Free PMC article.

9

System-wide identification and prioritization of enzyme substrates by thermal analysis.

Saei AA, Beusch CM, Sabatier P, Wells JA, Gharibi H, Meng Z, Chernobrovkin A, Rodin S, Näreoja K, Thorsell AG, Karlberg T, Cheng Q, Lundström SL, Gaetani M, Végvári Á, Arnér ESJ, Schüler H, Zubarev RA. Saei AA, et al. Among authors: schuler h. Nat Commun. 2021 Feb 26;12(1):1296. doi: 10.1038/s41467-021-21540-6. Nat Commun. 2021. PMID: 33637753 Free PMC article.

10

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.

Wahlberg E, Karlberg T, Kouznetsova E, Markova N, Macchiarulo A, Thorsell AG, Pol E, Frostell Å, Ekblad T, Öncü D, Kull B, Robertson GM, Pellicciari R, Schüler H, Weigelt J. Wahlberg E, et al. Among authors: schuler h. Nat Biotechnol. 2012 Feb 19;30(3):283-8. doi: 10.1038/nbt.2121. Nat Biotechnol. 2012. PMID: 22343925

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