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Adapting to stress - chaperome networks in cancer.
Joshi S, Wang T, Araujo TLS, Sharma S, Brodsky JL, Chiosis G. Joshi S, et al. Among authors: chiosis g. Nat Rev Cancer. 2018 Sep;18(9):562-575. doi: 10.1038/s41568-018-0020-9. Nat Rev Cancer. 2018. PMID: 29795326 Free PMC article. Review.
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G. Rodina A, et al. Among authors: chiosis g. Nat Chem Biol. 2007 Aug;3(8):498-507. doi: 10.1038/nchembio.2007.10. Epub 2007 Jul 1. Nat Chem Biol. 2007. PMID: 17603540
The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding.
Goeckeler JL, Petruso AP, Aguirre J, Clement CC, Chiosis G, Brodsky JL. Goeckeler JL, et al. Among authors: chiosis g. FEBS Lett. 2008 Jul 9;582(16):2393-6. doi: 10.1016/j.febslet.2008.05.047. Epub 2008 Jun 6. FEBS Lett. 2008. PMID: 18539149 Free PMC article.
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.
Kang Y, Taldone T, Patel HJ, Patel PD, Rodina A, Gozman A, Maharaj R, Clement CC, Patel MR, Brodsky JL, Young JC, Chiosis G. Kang Y, et al. Among authors: chiosis g. J Med Chem. 2014 Feb 27;57(4):1188-207. doi: 10.1021/jm401551n. Epub 2014 Feb 18. J Med Chem. 2014. PMID: 24548207 Free PMC article.
Selective targeting of the stress chaperome as a therapeutic strategy.
Taldone T, Ochiana SO, Patel PD, Chiosis G. Taldone T, et al. Among authors: chiosis g. Trends Pharmacol Sci. 2014 Nov;35(11):592-603. doi: 10.1016/j.tips.2014.09.001. Epub 2014 Sep 25. Trends Pharmacol Sci. 2014. PMID: 25262919 Free PMC article. Review.
171 results