Held J - Search Results

1

Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a]pyridine-Capped Selective HDAC6 Inhibitors.

Mackwitz MKW, Hamacher A, Osko JD, Held J, Schöler A, Christianson DW, Kassack MU, Hansen FK. Mackwitz MKW, et al. Among authors: held j. Org Lett. 2018 Jun 1;20(11):3255-3258. doi: 10.1021/acs.orglett.8b01118. Epub 2018 May 23. Org Lett. 2018. PMID: 29790770 Free PMC article.

2

Synthesis, antimalarial properties, and SAR studies of alkoxyurea-based HDAC inhibitors.

Hansen FK, Skinner-Adams TS, Duffy S, Marek L, Sumanadasa SD, Kuna K, Held J, Avery VM, Andrews KT, Kurz T. Hansen FK, et al. Among authors: held j. ChemMedChem. 2014 Mar;9(3):665-70. doi: 10.1002/cmdc.201300469. Epub 2014 Feb 4. ChemMedChem. 2014. PMID: 24497437

3

Design and Synthesis of Novel Anti-Plasmodial Histone Deacetylase Inhibitors Containing an Alkoxyamide Connecting Unit.

Alves Avelar LA, Held J, Engel JA, Sureechatchaiyan P, Hansen FK, Hamacher A, Kassack MU, Mordmüller B, Andrews KT, Kurz T. Alves Avelar LA, et al. Among authors: held j. Arch Pharm (Weinheim). 2017 Apr;350(3-4). doi: 10.1002/ardp.201600347. Epub 2017 Mar 20. Arch Pharm (Weinheim). 2017. PMID: 28317157

4

One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.

Diedrich D, Stenzel K, Hesping E, Antonova-Koch Y, Gebru T, Duffy S, Fisher G, Schöler A, Meister S, Kurz T, Avery VM, Winzeler EA, Held J, Andrews KT, Hansen FK. Diedrich D, et al. Among authors: held j. Eur J Med Chem. 2018 Oct 5;158:801-813. doi: 10.1016/j.ejmech.2018.09.018. Epub 2018 Sep 7. Eur J Med Chem. 2018. PMID: 30245402 Free PMC article.

5

Structure-Activity and Structure-Toxicity Relationships of Peptoid-Based Histone Deacetylase Inhibitors with Dual-Stage Antiplasmodial Activity.

Mackwitz MKW, Hesping E, Antonova-Koch Y, Diedrich D, Woldearegai TG, Skinner-Adams T, Clarke M, Schöler A, Limbach L, Kurz T, Winzeler EA, Held J, Andrews KT, Hansen FK. Mackwitz MKW, et al. Among authors: held j. ChemMedChem. 2019 May 6;14(9):912-926. doi: 10.1002/cmdc.201800808. Epub 2019 Feb 19. ChemMedChem. 2019. PMID: 30664827 Free PMC article.

6

Histone deacetylase inhibitors with high in vitro activities against Plasmodium falciparum isolates collected from Gabonese children and adults.

Koehne E, Kreidenweiss A, Zoleko Manego R, McCall M, Mombo-Ngoma G, Mackwitz MKW, Hansen FK, Held J. Koehne E, et al. Among authors: held j. Sci Rep. 2019 Nov 22;9(1):17336. doi: 10.1038/s41598-019-53912-w. Sci Rep. 2019. PMID: 31758015 Free PMC article.

7

Investigation of the in vitro and in vivo efficacy of peptoid-based HDAC inhibitors with dual-stage antiplasmodial activity.

Mackwitz MKW, Hesping E, Eribez K, Schöler A, Antonova-Koch Y, Held J, Winzeler EA, Andrews KT, Hansen FK. Mackwitz MKW, et al. Among authors: held j. Eur J Med Chem. 2021 Feb 5;211:113065. doi: 10.1016/j.ejmech.2020.113065. Epub 2020 Dec 5. Eur J Med Chem. 2021. PMID: 33360801

8

Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin-HDAC Inhibitor Hybrids as Multitarget Drugs.

von Bredow L, Schäfer TM, Hogenkamp J, Tretbar M, Stopper D, Kraft FB, Schliehe-Diecks J, Schöler A, Borkhardt A, Bhatia S, Held J, Hansen FK. von Bredow L, et al. Among authors: held j. Pharmaceuticals (Basel). 2022 Mar 9;15(3):333. doi: 10.3390/ph15030333. Pharmaceuticals (Basel). 2022. PMID: 35337131 Free PMC article.

9

Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC.

Konzuch S, Umeda T, Held J, Hähn S, Brücher K, Lienau C, Behrendt CT, Gräwert T, Bacher A, Illarionov B, Fischer M, Mordmüller B, Tanaka N, Kurz T. Konzuch S, et al. Among authors: held j. J Med Chem. 2014 Nov 13;57(21):8827-38. doi: 10.1021/jm500850y. Epub 2014 Oct 20. J Med Chem. 2014. PMID: 25254502

10

α-Substituted β-oxa isosteres of fosmidomycin: synthesis and biological evaluation.

Brücher K, Illarionov B, Held J, Tschan S, Kunfermann A, Pein MK, Bacher A, Gräwert T, Maes L, Mordmüller B, Fischer M, Kurz T. Brücher K, et al. Among authors: held j. J Med Chem. 2012 Jul 26;55(14):6566-75. doi: 10.1021/jm300652f. Epub 2012 Jul 11. J Med Chem. 2012. PMID: 22731758

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