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A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair.
Bharti SK, Sommers JA, Awate S, Bellani MA, Khan I, Bradley L, King GA, Seol Y, Vidhyasagar V, Wu Y, Abe T, Kobayashi K, Shin-Ya K, Kitao H, Wold MS, Branzei D, Neuman KC, Brosh RM Jr. Bharti SK, et al. Nucleic Acids Res. 2018 Jul 6;46(12):6238-6256. doi: 10.1093/nar/gky403. Nucleic Acids Res. 2018. PMID: 29788478 Free PMC article.
Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: SUBSTRATE SPECIFICITY, DNA BRANCH MIGRATION, AND ABILITY TO OVERCOME BLOCKADES TO DNA UNWINDING.
Khan I, Crouch JD, Bharti SK, Sommers JA, Carney SM, Yakubovskaya E, Garcia-Diaz M, Trakselis MA, Brosh RM Jr. Khan I, et al. Among authors: bharti sk. J Biol Chem. 2016 Jul 1;291(27):14324-14339. doi: 10.1074/jbc.M115.712026. Epub 2016 May 11. J Biol Chem. 2016. PMID: 27226550 Free PMC article.
Fine-tuning DNA repair by protein acetylation.
Bharti SK, Brosh RM Jr. Bharti SK, et al. Cell Cycle. 2016 Aug 2;15(15):1952-3. doi: 10.1080/15384101.2016.1191250. Epub 2016 Jun 13. Cell Cycle. 2016. PMID: 27292584 Free PMC article. No abstract available.
DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
Bharti SK, Sommers JA, Zhou J, Kaplan DL, Spelbrink JN, Mergny JL, Brosh RM Jr. Bharti SK, et al. J Biol Chem. 2014 Oct 24;289(43):29975-93. doi: 10.1074/jbc.M114.567073. Epub 2014 Sep 5. J Biol Chem. 2014. PMID: 25193669 Free PMC article.
Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro.
Butler TJ, Estep KN, Sommers JA, Maul RW, Moore AZ, Bandinelli S, Cucca F, Tuke MA, Wood AR, Bharti SK, Bogenhagen DF, Yakubovskaya E, Garcia-Diaz M, Guilliam TA, Byrd AK, Raney KD, Doherty AJ, Ferrucci L, Schlessinger D, Ding J, Brosh RM. Butler TJ, et al. Among authors: bharti sk. Hum Mol Genet. 2020 May 28;29(8):1292-1309. doi: 10.1093/hmg/ddaa043. Hum Mol Genet. 2020. PMID: 32191790 Free PMC article.
A Long Noncoding RNA Regulates Sister Chromatid Cohesion.
Marchese FP, Grossi E, Marín-Béjar O, Bharti SK, Raimondi I, González J, Martínez-Herrera DJ, Athie A, Amadoz A, Brosh RM Jr, Huarte M. Marchese FP, et al. Among authors: bharti sk. Mol Cell. 2016 Aug 4;63(3):397-407. doi: 10.1016/j.molcel.2016.06.031. Epub 2016 Jul 28. Mol Cell. 2016. PMID: 27477908 Free PMC article.
79 results