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The Combination of Patient Profiling and Preclinical Studies in a Mouse Model Based on NOD/Scid IL2Rγ null Mice Reconstituted With Peripheral Blood Mononuclear Cells From Patients With Ulcerative Colitis May Lead to Stratification of Patients for Treatment With Adalimumab.
Jodeleit H, Caesar J, Villarroel Aguilera C, Sterz S, Holdt L, Beigel F, Stallhofer J, Breiteneicher S, Bartnik E, Siebeck M, Gropp R. Jodeleit H, et al. Inflamm Bowel Dis. 2020 Mar 4;26(4):557-569. doi: 10.1093/ibd/izz284. Inflamm Bowel Dis. 2020. PMID: 31782956 Free PMC article.
Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγnull mice reconstituted with human peripheral blood mononuclear cells.
Jodeleit H, Winkelmann P, Caesar J, Sterz S, Holdt LM, Beigel F, Stallhofer J, Breiteneicher S, Bartnik E, Leeuw T, Siebeck M, Gropp R. Jodeleit H, et al. Dis Model Mech. 2021 Jan 1;14(1):dmm046995. doi: 10.1242/dmm.046995. Epub 2021 Jan 21. Dis Model Mech. 2021. PMID: 33293281 Free PMC article.