Pennington MW - Search Results

1

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI. Rangaraju S, et al. Among authors: pennington mw. Mol Neurodegener. 2018 May 21;13(1):24. doi: 10.1186/s13024-018-0254-8. Mol Neurodegener. 2018. PMID: 29784049 Free PMC article.

2

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation.

Rangaraju S, Raza SA, Pennati A, Deng Q, Dammer EB, Duong D, Pennington MW, Tansey MG, Lah JJ, Betarbet R, Seyfried NT, Levey AI. Rangaraju S, et al. Among authors: pennington mw. J Neuroinflammation. 2017 Jun 26;14(1):128. doi: 10.1186/s12974-017-0906-6. J Neuroinflammation. 2017. PMID: 28651603 Free PMC article.

3

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis.

Rangaraju S, Chi V, Pennington MW, Chandy KG. Rangaraju S, et al. Among authors: pennington mw. Expert Opin Ther Targets. 2009 Aug;13(8):909-24. doi: 10.1517/14728220903018957. Expert Opin Ther Targets. 2009. PMID: 19538097 Review.

4

Potassium channel modulation by a toxin domain in matrix metalloprotease 23.

Rangaraju S, Khoo KK, Feng ZP, Crossley G, Nugent D, Khaytin I, Chi V, Pham C, Calabresi P, Pennington MW, Norton RS, Chandy KG. Rangaraju S, et al. Among authors: pennington mw. J Biol Chem. 2010 Mar 19;285(12):9124-36. doi: 10.1074/jbc.M109.071266. Epub 2009 Dec 4. J Biol Chem. 2010. PMID: 19965868 Free PMC article.

5

Blockade of Kv1.3 channels ameliorates radiation-induced brain injury.

Peng Y, Lu K, Li Z, Zhao Y, Wang Y, Hu B, Xu P, Shi X, Zhou B, Pennington M, Chandy KG, Tang Y. Peng Y, et al. Neuro Oncol. 2014 Apr;16(4):528-39. doi: 10.1093/neuonc/not221. Epub 2013 Dec 4. Neuro Oncol. 2014. PMID: 24305723 Free PMC article.

6

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes.

Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C, Chauhan S, Orzel A, Inoue T, Hu X, Moore RV, Norton RS, Chandy KG. Pennington MW, et al. Mol Pharmacol. 2009 Apr;75(4):762-73. doi: 10.1124/mol.108.052704. Epub 2009 Jan 2. Mol Pharmacol. 2009. PMID: 19122005 Free PMC article.

7

Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.

Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD. Matheu MP, et al. Among authors: pennington mw. Immunity. 2008 Oct 17;29(4):602-14. doi: 10.1016/j.immuni.2008.07.015. Epub 2008 Oct 2. Immunity. 2008. PMID: 18835197 Free PMC article.

8

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3.

Pennington MW, Harunur Rashid M, Tajhya RB, Beeton C, Kuyucak S, Norton RS. Pennington MW, et al. FEBS Lett. 2012 Nov 16;586(22):3996-4001. doi: 10.1016/j.febslet.2012.09.038. Epub 2012 Oct 9. FEBS Lett. 2012. PMID: 23063513 Free PMC article.

9

Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia.

Nguyen HM, di Lucente J, Chen YJ, Cui Y, Ibrahim RH, Pennington MW, Jin LW, Maezawa I, Wulff H. Nguyen HM, et al. Among authors: pennington mw. Glia. 2020 Nov;68(11):2377-2394. doi: 10.1002/glia.23847. Epub 2020 Jun 11. Glia. 2020. PMID: 32525239 Free PMC article.

10

KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis.

Tanner MR, Pennington MW, Chauhan SS, Laragione T, Gulko PS, Beeton C. Tanner MR, et al. Among authors: pennington mw. Arthritis Res Ther. 2019 Jan 7;21(1):6. doi: 10.1186/s13075-018-1783-9. Arthritis Res Ther. 2019. PMID: 30612588 Free PMC article.

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