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Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
Stöppler D, Macpherson A, Smith-Penzel S, Basse N, Lecomte F, Deboves H, Taylor RD, Norman T, Porter J, Waters LC, Westwood M, Cossins B, Cain K, White J, Griffin R, Prosser C, Kelm S, Sullivan AH, Fox D 3rd, Carr MD, Henry A, Taylor R, Meier BH, Oschkinat H, Lawson AD. Stöppler D, et al. Among authors: griffin r. PLoS Biol. 2018 May 21;16(5):e2006192. doi: 10.1371/journal.pbio.2006192. eCollection 2018 May. PLoS Biol. 2018. PMID: 29782488 Free PMC article.
Conformational heterogeneity in antibody-protein antigen recognition: implications for high affinity protein complex formation.
Addis PW, Hall CJ, Bruton S, Veverka V, Wilkinson IC, Muskett FW, Renshaw PS, Prosser CE, Carrington B, Lawson ADG, Griffin R, Taylor RJ, Waters LC, Henry AJ, Carr MD. Addis PW, et al. Among authors: griffin r. J Biol Chem. 2014 Mar 7;289(10):7200-7210. doi: 10.1074/jbc.M113.492215. Epub 2014 Jan 16. J Biol Chem. 2014. PMID: 24436329 Free PMC article.
Structure and interactions of the human programmed cell death 1 receptor.
Cheng X, Veverka V, Radhakrishnan A, Waters LC, Muskett FW, Morgan SH, Huo J, Yu C, Evans EJ, Leslie AJ, Griffiths M, Stubberfield C, Griffin R, Henry AJ, Jansson A, Ladbury JE, Ikemizu S, Carr MD, Davis SJ. Cheng X, et al. Among authors: griffin r. J Biol Chem. 2013 Apr 26;288(17):11771-85. doi: 10.1074/jbc.M112.448126. Epub 2013 Feb 15. J Biol Chem. 2013. PMID: 23417675 Free PMC article.
Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
Adams R, Burnley RJ, Valenzano CR, Qureshi O, Doyle C, Lumb S, Del Carmen Lopez M, Griffin R, McMillan D, Taylor RD, Meier C, Mori P, Griffin LM, Wernery U, Kinne J, Rapecki S, Baker TS, Lawson AD, Wright M, Ettorre A. Adams R, et al. Among authors: griffin lm, griffin r. Sci Rep. 2017 Jan 30;7:37716. doi: 10.1038/srep37716. Sci Rep. 2017. PMID: 28134246 Free PMC article.
Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau.
Courade JP, Angers R, Mairet-Coello G, Pacico N, Tyson K, Lightwood D, Munro R, McMillan D, Griffin R, Baker T, Starkie D, Nan R, Westwood M, Mushikiwabo ML, Jung S, Odede G, Sweeney B, Popplewell A, Burgess G, Downey P, Citron M. Courade JP, et al. Among authors: griffin r. Acta Neuropathol. 2018 Nov;136(5):729-745. doi: 10.1007/s00401-018-1911-2. Epub 2018 Sep 20. Acta Neuropathol. 2018. PMID: 30238240 Free PMC article.
Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions.
Rowley TF, Peters SJ, Aylott M, Griffin R, Davies NL, Healy LJ, Cutler RM, Eddleston A, Pither TL, Sopp JM, Zaccheo O, Fossati G, Cain K, Ventom AM, Hailu H, Ward EJ, Sherington J, Brennan FR, Fallah-Arani F, Humphreys DP. Rowley TF, et al. Among authors: griffin r. Commun Biol. 2018 Sep 14;1:146. doi: 10.1038/s42003-018-0149-9. eCollection 2018. Commun Biol. 2018. PMID: 30272022 Free PMC article.
Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions.
Qureshi OS, Rowley TF, Junker F, Peters SJ, Crilly S, Compson J, Eddleston A, Björkelund H, Greenslade K, Parkinson M, Davies NL, Griffin R, Pither TL, Cain K, Christodoulou L, Staelens L, Ward E, Tibbitts J, Kiessling A, Smith B, Brennan FR, Malmqvist M, Fallah-Arani F, Humphreys DP. Qureshi OS, et al. Among authors: griffin r. Sci Rep. 2017 Dec 6;7(1):17049. doi: 10.1038/s41598-017-17255-8. Sci Rep. 2017. PMID: 29213127 Free PMC article.
In vitro and in vivo characterisation of anti-murine IL-13 antibodies recognising distinct functional epitopes.
Berry LM, Adams R, Airey M, Bracher MG, Bourne T, Carrington B, Cross AS, Davies GC, Finney HM, Foulkes R, Gozzard N, Griffin RA, Hailu H, Lamour SD, Lawson AD, Lightwood DJ, McKnight AJ, O'Dowd VL, Oxbrow AK, Popplewell AG, Shaw S, Stephens PE, Sweeney B, Tomlinson KL, Uhe C, Palframan RT. Berry LM, et al. Among authors: griffin ra. Int Immunopharmacol. 2009 Feb;9(2):201-6. doi: 10.1016/j.intimp.2008.11.001. Epub 2008 Nov 27. Int Immunopharmacol. 2009. PMID: 19041426
Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms.
Ramberger M, Berretta A, Tan JMM, Sun B, Michael S, Yeo T, Theorell J, Bashford-Rogers R, Paneva S, O'Dowd V, Dedi N, Topia S, Griffin R, Ramirez-Franco J, El Far O, Baulac S, Leite MI, Sen A, Jeans A, McMillan D, Marshall D, Anthony D, Lightwood D, Waters P, Irani SR. Ramberger M, et al. Among authors: griffin r. Brain. 2020 Jun 1;143(6):1731-1745. doi: 10.1093/brain/awaa104. Brain. 2020. PMID: 32437528 Free PMC article.
A phase 1 study to assess the absolute bioavailability, mass balance, pharmacokinetics, metabolism, and excretion of [14C]-mobocertinib, an oral inhibitor of EGFR exon 20 insertion mutations, in healthy participants.
Hanley MJ, Zhang S, Griffin R, Zhu SX, Fram RJ, Lin J, Venkatakrishnan K, Gupta N. Hanley MJ, et al. Among authors: griffin r. Invest New Drugs. 2024 May 24. doi: 10.1007/s10637-024-01446-y. Online ahead of print. Invest New Drugs. 2024. PMID: 38789848
1,436 results