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Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC.
Cloughesy TF, Landolfi J, Vogelbaum MA, Ostertag D, Elder JB, Bloomfield S, Carter B, Chen CC, Kalkanis SN, Kesari S, Lai A, Lee IY, Liau LM, Mikkelsen T, Nghiemphu P, Piccioni D, Accomando W, Diago OR, Hogan DJ, Gammon D, Kasahara N, Kheoh T, Jolly DJ, Gruber HE, Das A, Walbert T. Cloughesy TF, et al. Among authors: kasahara n. Neuro Oncol. 2018 Sep 3;20(10):1383-1392. doi: 10.1093/neuonc/noy075. Neuro Oncol. 2018. PMID: 29762717 Free PMC article. Clinical Trial.
Retroviral replicating vectors in cancer.
Logg CR, Robbins JM, Jolly DJ, Gruber HE, Kasahara N. Logg CR, et al. Among authors: kasahara n. Methods Enzymol. 2012;507:199-228. doi: 10.1016/B978-0-12-386509-0.00011-9. Methods Enzymol. 2012. PMID: 22365776 Free PMC article.
Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression.
Perez OD, Logg CR, Hiraoka K, Diago O, Burnett R, Inagaki A, Jolson D, Amundson K, Buckley T, Lohse D, Lin A, Burrascano C, Ibanez C, Kasahara N, Gruber HE, Jolly DJ. Perez OD, et al. Among authors: kasahara n. Mol Ther. 2012 Sep;20(9):1689-98. doi: 10.1038/mt.2012.83. Epub 2012 May 1. Mol Ther. 2012. PMID: 22547150 Free PMC article.
Combined alloreactive CTL cellular therapy with prodrug activator gene therapy in a model of breast cancer metastatic to the brain.
Hickey MJ, Malone CC, Erickson KL, Lin A, Soto H, Ha ET, Kamijima S, Inagaki A, Takahashi M, Kato Y, Kasahara N, Mueller BM, Kruse CA. Hickey MJ, et al. Among authors: kasahara n. Clin Cancer Res. 2013 Aug 1;19(15):4137-48. doi: 10.1158/1078-0432.CCR-12-3735. Epub 2013 Jun 18. Clin Cancer Res. 2013. PMID: 23780889 Free PMC article.
MicroRNA 142-3p attenuates spread of replicating retroviral vector in hematopoietic lineage-derived cells while maintaining an antiviral immune response.
Lin AH, Timberlake N, Logg CR, Liu Y, Kamijima S, Diago O, Wong K, Gammon DK, Ostertag D, Hacke K, Yang EC, Gruber H, Kasahara N, Jolly DJ. Lin AH, et al. Among authors: kasahara n. Hum Gene Ther. 2014 Aug;25(8):759-71. doi: 10.1089/hum.2012.216. Epub 2014 Jun 18. Hum Gene Ther. 2014. PMID: 24825189 Free PMC article.
Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector.
Takahashi M, Valdes G, Hiraoka K, Inagaki A, Kamijima S, Micewicz E, Gruber HE, Robbins JM, Jolly DJ, McBride WH, Iwamoto KS, Kasahara N. Takahashi M, et al. Among authors: kasahara n. Cancer Gene Ther. 2014 Oct;21(10):405-410. doi: 10.1038/cgt.2014.38. Epub 2014 Oct 10. Cancer Gene Ther. 2014. PMID: 25301172 Free PMC article.
Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model.
Huang TT, Parab S, Burnett R, Diago O, Ostertag D, Hofman FM, Espinoza FL, Martin B, Ibañez CE, Kasahara N, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM. Huang TT, et al. Among authors: kasahara n. Hum Gene Ther. 2015 Feb;26(2):82-93. doi: 10.1089/hum.2014.100. Epub 2015 Jan 19. Hum Gene Ther. 2015. PMID: 25419577 Free PMC article.
333 results