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Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain.
J Med Chem. 2018 Jun 28;61(12):5122-5137. doi: 10.1021/acs.jmedchem.8b00002. Epub 2018 May 23.
J Med Chem. 2018.
PMID: 29733614
Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.
Nakahara K, Fuchino K, Komano K, Asada N, Tadano G, Hasegawa T, Yamamoto T, Sako Y, Ogawa M, Unemura C, Hosono M, Ito H, Sakaguchi G, Ando S, Ohnishi S, Kido Y, Fukushima T, Dhuyvetter D, Borghys H, Gijsen HJM, Yamano Y, Iso Y, Kusakabe KI.
Nakahara K, et al. Among authors: unemura c.
J Med Chem. 2018 Jul 12;61(13):5525-5546. doi: 10.1021/acs.jmedchem.8b00011. Epub 2018 Jun 14.
J Med Chem. 2018.
PMID: 29775538
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New Highly Selective BACE1 Inhibitors and Their Effects on Dendritic Spine Density In Vivo.
Pratsch K, Unemura C, Ito M, Lichtenthaler SF, Horiguchi N, Herms J.
Pratsch K, et al. Among authors: unemura c.
Int J Mol Sci. 2023 Jul 31;24(15):12283. doi: 10.3390/ijms241512283.
Int J Mol Sci. 2023.
PMID: 37569661
Free PMC article.
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Allosteric inhibition of phosphodiesterase 4D induces biphasic memory-enhancing effects associated with learning-activated signaling pathways.
Jino K, Miyamoto K, Kanbara T, Unemura C, Horiguchi N, Ago Y.
Jino K, et al. Among authors: unemura c.
Psychopharmacology (Berl). 2024 Apr;241(4):805-816. doi: 10.1007/s00213-023-06510-8. Epub 2023 Dec 19.
Psychopharmacology (Berl). 2024.
PMID: 38114603
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