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Page 1
Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain.
Fuchino K, Mitsuoka Y, Masui M, Kurose N, Yoshida S, Komano K, Yamamoto T, Ogawa M, Unemura C, Hosono M, Ito H, Sakaguchi G, Ando S, Ohnishi S, Kido Y, Fukushima T, Miyajima H, Hiroyama S, Koyabu K, Dhuyvetter D, Borghys H, Gijsen HJM, Yamano Y, Iso Y, Kusakabe KI. Fuchino K, et al. Among authors: hosono m. J Med Chem. 2018 Jun 28;61(12):5122-5137. doi: 10.1021/acs.jmedchem.8b00002. Epub 2018 May 23. J Med Chem. 2018. PMID: 29733614
Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.
Nakahara K, Fuchino K, Komano K, Asada N, Tadano G, Hasegawa T, Yamamoto T, Sako Y, Ogawa M, Unemura C, Hosono M, Ito H, Sakaguchi G, Ando S, Ohnishi S, Kido Y, Fukushima T, Dhuyvetter D, Borghys H, Gijsen HJM, Yamano Y, Iso Y, Kusakabe KI. Nakahara K, et al. Among authors: hosono m. J Med Chem. 2018 Jul 12;61(13):5525-5546. doi: 10.1021/acs.jmedchem.8b00011. Epub 2018 Jun 14. J Med Chem. 2018. PMID: 29775538
Conformational restriction approach to β-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode.
Yonezawa S, Yamamoto T, Yamakawa H, Muto C, Hosono M, Hattori K, Higashino K, Yutsudo T, Iwamoto H, Kondo Y, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: hosono m. J Med Chem. 2012 Oct 25;55(20):8838-58. doi: 10.1021/jm3011405. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22998419
Conformational restriction approach to β-secretase (BACE1) inhibitors III: effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.
Yonezawa S, Fujiwara K, Yamamoto T, Hattori K, Yamakawa H, Muto C, Hosono M, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: hosono m. Bioorg Med Chem. 2013 Nov 1;21(21):6506-22. doi: 10.1016/j.bmc.2013.08.036. Epub 2013 Aug 28. Bioorg Med Chem. 2013. PMID: 24051074
Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.
Yonezawa S, Yamakawa H, Muto C, Hosono M, Yamamoto T, Hattori K, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: hosono m. Bioorg Med Chem Lett. 2013 May 15;23(10):2912-5. doi: 10.1016/j.bmcl.2013.03.056. Epub 2013 Mar 26. Bioorg Med Chem Lett. 2013. PMID: 23562056
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y. Nishitomi K, et al. Among authors: hosono m. J Neurochem. 2006 Dec;99(6):1555-63. doi: 10.1111/j.1471-4159.2006.04178.x. Epub 2006 Nov 2. J Neurochem. 2006. PMID: 17083447 Free article.
Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor.
Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M. Itoh N, et al. Among authors: hosono m. Neurodegener Dis. 2009;6(5-6):230-9. doi: 10.1159/000236902. Epub 2009 Sep 9. Neurodegener Dis. 2009. PMID: 19738368
Association of seasonal changes in circulating cortisol concentrations with the expression of cortisol biosynthetic enzymes and a glucocorticoid receptor in the blubber of common bottlenose dolphin.
Suzuki M, Funasaka N, Sato Y, Inamori D, Watanabe Y, Ozaki M, Hosono M, Shindo H, Kawamura K, Tatsukawa T, Yoshioka M. Suzuki M, et al. Among authors: hosono m. Gen Comp Endocrinol. 2024 Jun 1;352:114516. doi: 10.1016/j.ygcen.2024.114516. Epub 2024 Apr 8. Gen Comp Endocrinol. 2024. PMID: 38593942
545 results