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The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A. Martinez Hernandez A, et al. Among authors: fuhrmann m. EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825. EMBO Mol Med. 2018. PMID: 29208638 Free PMC article.
Memory trace interference impairs recall in a mouse model of Alzheimer's disease.
Poll S, Mittag M, Musacchio F, Justus LC, Giovannetti EA, Steffen J, Wagner J, Zohren L, Schoch S, Schmidt B, Jackson WS, Ehninger D, Fuhrmann M. Poll S, et al. Among authors: fuhrmann m. Nat Neurosci. 2020 Aug;23(8):952-958. doi: 10.1038/s41593-020-0652-4. Epub 2020 Jun 8. Nat Neurosci. 2020. PMID: 32514139
Hippocampal hyperactivity in a rat model of Alzheimer's disease.
Sosulina L, Mittag M, Geis HR, Hoffmann K, Klyubin I, Qi Y, Steffen J, Friedrichs D, Henneberg N, Fuhrmann F, Justus D, Keppler K, Cuello AC, Rowan MJ, Fuhrmann M, Remy S. Sosulina L, et al. Among authors: fuhrmann f, fuhrmann m. J Neurochem. 2021 Jun;157(6):2128-2144. doi: 10.1111/jnc.15323. Epub 2021 Mar 5. J Neurochem. 2021. PMID: 33583024 Free article.
131 results