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A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma.
Gedeon PC, Schaller TH, Chitneni SK, Choi BD, Kuan CT, Suryadevara CM, Snyder DJ, Schmittling RJ, Szafranski SE, Cui X, Healy PN, Herndon JE 2nd, McLendon RE, Keir ST, Archer GE, Reap EA, Sanchez-Perez L, Bigner DD, Sampson JH. Gedeon PC, et al. Among authors: kuan ct. Clin Cancer Res. 2018 Aug 1;24(15):3611-3631. doi: 10.1158/1078-0432.CCR-17-0126. Epub 2018 Apr 27. Clin Cancer Res. 2018. PMID: 29703821 Free PMC article.
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
Kuan CT, Wakiya K, Herndon JE 2nd, Lipp ES, Pegram CN, Riggins GJ, Rasheed A, Szafranski SE, McLendon RE, Wikstrand CJ, Bigner DD. Kuan CT, et al. BMC Cancer. 2010 Sep 1;10:468. doi: 10.1186/1471-2407-10-468. BMC Cancer. 2010. PMID: 20809959 Free PMC article.
Bispecific antibodies engage T cells for antitumor immunotherapy.
Choi BD, Cai M, Bigner DD, Mehta AI, Kuan CT, Sampson JH. Choi BD, et al. Among authors: kuan ct. Expert Opin Biol Ther. 2011 Jul;11(7):843-53. doi: 10.1517/14712598.2011.572874. Epub 2011 Mar 30. Expert Opin Biol Ther. 2011. PMID: 21449821 Review.
EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss.
Sampson JH, Choi BD, Sanchez-Perez L, Suryadevara CM, Snyder DJ, Flores CT, Schmittling RJ, Nair SK, Reap EA, Norberg PK, Herndon JE 2nd, Kuan CT, Morgan RA, Rosenberg SA, Johnson LA. Sampson JH, et al. Among authors: kuan ct. Clin Cancer Res. 2014 Feb 15;20(4):972-84. doi: 10.1158/1078-0432.CCR-13-0709. Epub 2013 Dec 18. Clin Cancer Res. 2014. PMID: 24352643 Free PMC article.
44 results