Goldberg DE - Search Results

1

Development of piperazine-based hydroxamic acid inhibitors against falcilysin, an essential malarial protease.

Chance JP, Fejzic H, Hernandez O, Istvan ES, Andaya A, Maslov N, Aispuro R, Crisanto T, Nguyen H, Vidal B, Serrano W, Kuwahara B, Pugne Andanado C, Goldberg DE, Mallari JP. Chance JP, et al. Among authors: goldberg de. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1846-1848. doi: 10.1016/j.bmcl.2018.04.010. Epub 2018 Apr 19. Bioorg Med Chem Lett. 2018. PMID: 29691139

2

Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II.

Haque TS, Skillman AG, Lee CE, Habashita H, Gluzman IY, Ewing TJ, Goldberg DE, Kuntz ID, Ellman JA. Haque TS, et al. Among authors: goldberg de. J Med Chem. 1999 Apr 22;42(8):1428-40. doi: 10.1021/jm980641t. J Med Chem. 1999. PMID: 10212129

3

Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum.

Eggleson KK, Duffin KL, Goldberg DE. Eggleson KK, et al. Among authors: goldberg de. J Biol Chem. 1999 Nov 5;274(45):32411-7. doi: 10.1074/jbc.274.45.32411. J Biol Chem. 1999. PMID: 10542284 Free article.

4

Novel and potent anti-malarial agents.

Brinner KM, Mi Kim J, Habashita H, Gluzman IY, Goldberg DE, Ellman JA. Brinner KM, et al. Among authors: goldberg de. Bioorg Med Chem. 2002 Nov;10(11):3649-61. doi: 10.1016/s0968-0896(02)00207-9. Bioorg Med Chem. 2002. PMID: 12213481

5

Plasmodium falciparum falcilysin: a metalloprotease with dual specificity.

Murata CE, Goldberg DE. Murata CE, et al. Among authors: goldberg de. J Biol Chem. 2003 Sep 26;278(39):38022-8. doi: 10.1074/jbc.M306842200. Epub 2003 Jul 22. J Biol Chem. 2003. PMID: 12876284 Free article.

6

Distal substrate interactions enhance plasmepsin activity.

Istvan ES, Goldberg DE. Istvan ES, et al. Among authors: goldberg de. J Biol Chem. 2005 Feb 25;280(8):6890-6. doi: 10.1074/jbc.M412086200. Epub 2004 Dec 1. J Biol Chem. 2005. PMID: 15574427 Free article.

7

Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors.

Parikh S, Gut J, Istvan E, Goldberg DE, Havlir DV, Rosenthal PJ. Parikh S, et al. Among authors: goldberg de. Antimicrob Agents Chemother. 2005 Jul;49(7):2983-5. doi: 10.1128/AAC.49.7.2983-2985.2005. Antimicrob Agents Chemother. 2005. PMID: 15980379 Free PMC article.

8

Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems.

Liu J, Istvan ES, Gluzman IY, Gross J, Goldberg DE. Liu J, et al. Among authors: goldberg de. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8840-5. doi: 10.1073/pnas.0601876103. Epub 2006 May 26. Proc Natl Acad Sci U S A. 2006. PMID: 16731623 Free PMC article.

9

Hemoglobin-degrading plasmepsin II is active as a monomer.

Liu J, Istvan ES, Goldberg DE. Liu J, et al. Among authors: goldberg de. J Biol Chem. 2006 Dec 15;281(50):38682-8. doi: 10.1074/jbc.M608535200. Epub 2006 Oct 13. J Biol Chem. 2006. PMID: 17040901 Free article.

10

A role for falcilysin in transit peptide degradation in the Plasmodium falciparum apicoplast.

Ponpuak M, Klemba M, Park M, Gluzman IY, Lamppa GK, Goldberg DE. Ponpuak M, et al. Among authors: goldberg de. Mol Microbiol. 2007 Jan;63(2):314-34. doi: 10.1111/j.1365-2958.2006.05443.x. Epub 2006 Oct 27. Mol Microbiol. 2007. PMID: 17074076 Free article.

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