Kwiatkowski J - Search Results

1

Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors.

Kwiatkowski J, Liu B, Tee DHY, Chen G, Ahmad NHB, Wong YX, Poh ZY, Ang SH, Tan ESW, Ong EH, Nurul Dinie, Poulsen A, Pendharkar V, Sangthongpitag K, Lee MA, Sepramaniam S, Ho SY, Cherian J, Hill J, Keller TH, Hung AW. Kwiatkowski J, et al. J Med Chem. 2018 May 24;61(10):4386-4396. doi: 10.1021/acs.jmedchem.8b00060. Epub 2018 May 4. J Med Chem. 2018. PMID: 29688013

2

Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues.

Kwiatkowski J, Baburajendran N, Poulsen A, Liu B, Tee DHY, Wong YX, Poh ZY, Ong EH, Dinie N, Cherian J, Jansson AE, Hill J, Keller TH, Hung AW. Kwiatkowski J, et al. ACS Med Chem Lett. 2019 Feb 15;10(3):318-323. doi: 10.1021/acsmedchemlett.8b00546. eCollection 2019 Mar 14. ACS Med Chem Lett. 2019. PMID: 30891133 Free PMC article.

3

Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.

Kwiatkowski J, Liu B, Pang S, Ahmad NHB, Wang G, Poulsen A, Yang H, Poh YR, Tee DHY, Ong E, Retna P, Dinie N, Kwek P, Wee JLK, Manoharan V, Low CB, Seah PG, Pendharkar V, Sangthongpitag K, Joy J, Baburajendran N, Jansson AE, Nacro K, Hill J, Keller TH, Hung AW. Kwiatkowski J, et al. J Med Chem. 2020 Jan 23;63(2):621-637. doi: 10.1021/acs.jmedchem.9b01582. Epub 2020 Jan 7. J Med Chem. 2020. PMID: 31910010

4

Asymmetric Michael addition of α-fluoro-α-nitro esters to nitroolefins: towards synthesis of α-fluoro-α-substituted amino acids.

Kwiatkowski J, Lu Y. Kwiatkowski J, et al. Org Biomol Chem. 2015 Feb 28;13(8):2350-9. doi: 10.1039/c4ob02486a. Org Biomol Chem. 2015. PMID: 25563391

5

Direct asymmetric Mannich reaction of phthalides: facile access to chiral substituted isoquinolines and isoquinolinones.

Luo J, Wang H, Zhong F, Kwiatkowski J, Xu LW, Lu Y. Luo J, et al. Among authors: kwiatkowski j. Chem Commun (Camb). 2012 May 16;48(39):4707-9. doi: 10.1039/c2cc31439h. Epub 2012 Apr 10. Chem Commun (Camb). 2012. PMID: 22488217

6

Highly diastereoselective and enantioselective direct Michael addition of phthalide derivatives to nitroolefins.

Luo J, Wang H, Zhong F, Kwiatkowski J, Xu LW, Lu Y. Luo J, et al. Among authors: kwiatkowski j. Chem Commun (Camb). 2013 Jun 28;49(51):5775-7. doi: 10.1039/c3cc42187b. Chem Commun (Camb). 2013. PMID: 23689801

7

Asymmetric synthesis of spiropyrazolones through phosphine-catalyzed [4+1] annulation.

Han X, Yao W, Wang T, Tan YR, Yan Z, Kwiatkowski J, Lu Y. Han X, et al. Among authors: kwiatkowski j. Angew Chem Int Ed Engl. 2014 May 26;53(22):5643-7. doi: 10.1002/anie.201311214. Epub 2014 Apr 15. Angew Chem Int Ed Engl. 2014. PMID: 24737675

8

Asymmetric Michael addition of α-fluoro-α-nitroalkanes to nitroolefins: facile preparation of fluorinated amines and tetrahydropyrimidines.

Kwiatkowski J, Lu Y. Kwiatkowski J, et al. Chem Commun (Camb). 2014 Aug 25;50(66):9313-6. doi: 10.1039/c4cc03513e. Chem Commun (Camb). 2014. PMID: 24999796

9

The direct asymmetric vinylogous aldol reaction of furanones with α-ketoesters: access to chiral γ-butenolides and glycerol derivatives.

Luo J, Wang H, Han X, Xu LW, Kwiatkowski J, Huang KW, Lu Y. Luo J, et al. Among authors: kwiatkowski j. Angew Chem Int Ed Engl. 2011 Feb 18;50(8):1861-4. doi: 10.1002/anie.201006316. Epub 2011 Jan 11. Angew Chem Int Ed Engl. 2011. PMID: 21328657 No abstract available.

10

Asymmetric Mannich reaction of fluorinated ketoesters with a tryptophan-derived bifunctional thiourea catalyst.

Han X, Kwiatkowski J, Xue F, Huang KW, Lu Y. Han X, et al. Among authors: kwiatkowski j. Angew Chem Int Ed Engl. 2009;48(41):7604-7. doi: 10.1002/anie.200903635. Angew Chem Int Ed Engl. 2009. PMID: 19739170 No abstract available.

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