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Localized conformational changes trigger the pH-induced fibrillogenesis of an amyloidogenic λ light chain protein.
Velázquez-López I, Valdés-García G, Romero Romero S, Maya Martínez R, Leal-Cervantes AI, Costas M, Sánchez-López R, Amero C, Pastor N, Fernández Velasco DA. Velázquez-López I, et al. Among authors: fernandez velasco da. Biochim Biophys Acta Gen Subj. 2018 Jul;1862(7):1656-1666. doi: 10.1016/j.bbagen.2018.04.014. Epub 2018 Apr 15. Biochim Biophys Acta Gen Subj. 2018. PMID: 29669263
Mutational and genetic determinants of λ6 light chain amyloidogenesis.
González-Andrade M, Becerril-Luján B, Sánchez-López R, Ceceña-Álvarez H, Pérez-Carreón JI, Ortiz E, Fernández-Velasco DA, del Pozo-Yauner L. González-Andrade M, et al. Among authors: fernandez velasco da. FEBS J. 2013 Dec;280(23):6173-83. doi: 10.1111/febs.12538. Epub 2013 Oct 28. FEBS J. 2013. PMID: 24107228 Free article.
The N-terminal strand modulates immunoglobulin light chain fibrillogenesis.
del Pozo-Yauner L, Wall JS, González Andrade M, Sánchez-López R, Rodríguez-Ambriz SL, Pérez Carreón JI, Ochoa-Leyva A, Fernández-Velasco DA. del Pozo-Yauner L, et al. Among authors: fernandez velasco da. Biochem Biophys Res Commun. 2014 Jan 10;443(2):495-9. doi: 10.1016/j.bbrc.2013.11.123. Epub 2013 Dec 7. Biochem Biophys Res Commun. 2014. PMID: 24321098
Site-directed mutagenesis reveals regions implicated in the stability and fiber formation of human λ3r light chains.
Villalba MI, Canul-Tec JC, Luna-Martínez OD, Sánchez-Alcalá R, Olamendi-Portugal T, Rudiño-Piñera E, Rojas S, Sánchez-López R, Fernández-Velasco DA, Becerril B. Villalba MI, et al. Among authors: fernandez velasco da. J Biol Chem. 2015 Jan 30;290(5):2577-92. doi: 10.1074/jbc.M114.629550. Epub 2014 Dec 11. J Biol Chem. 2015. PMID: 25505244 Free PMC article.
Stability and aggregation propensity do not fully account for the association of various germline variable domain gene segments with light chain amyloidosis.
Garay Sánchez SA, Rodríguez Álvarez FJ, Zavala-Padilla G, Mejia-Cristobal LM, Cruz-Rangel A, Costas M, Fernández Velasco DA, Melendez-Zajgla J, Del Pozo-Yauner L. Garay Sánchez SA, et al. Among authors: fernandez velasco da. Biol Chem. 2017 Apr 1;398(4):477-489. doi: 10.1515/hsz-2016-0178. Biol Chem. 2017. PMID: 27935845
Stabilizing an amyloidogenic λ6 light chain variable domain.
Luna-Martínez OD, Hernández-Santoyo A, Villalba-Velázquez MI, Sánchez-Alcalá R, Fernández-Velasco DA, Becerril B. Luna-Martínez OD, et al. Among authors: fernandez velasco da. FEBS J. 2017 Nov;284(21):3702-3717. doi: 10.1111/febs.14265. Epub 2017 Oct 12. FEBS J. 2017. PMID: 28898537 Free article.
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