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Localized conformational changes trigger the pH-induced fibrillogenesis of an amyloidogenic λ light chain protein.
Velázquez-López I, Valdés-García G, Romero Romero S, Maya Martínez R, Leal-Cervantes AI, Costas M, Sánchez-López R, Amero C, Pastor N, Fernández Velasco DA. Velázquez-López I, et al. Among authors: costas m. Biochim Biophys Acta Gen Subj. 2018 Jul;1862(7):1656-1666. doi: 10.1016/j.bbagen.2018.04.014. Epub 2018 Apr 15. Biochim Biophys Acta Gen Subj. 2018. PMID: 29669263
Stability and aggregation propensity do not fully account for the association of various germline variable domain gene segments with light chain amyloidosis.
Garay Sánchez SA, Rodríguez Álvarez FJ, Zavala-Padilla G, Mejia-Cristobal LM, Cruz-Rangel A, Costas M, Fernández Velasco DA, Melendez-Zajgla J, Del Pozo-Yauner L. Garay Sánchez SA, et al. Among authors: costas m. Biol Chem. 2017 Apr 1;398(4):477-489. doi: 10.1515/hsz-2016-0178. Biol Chem. 2017. PMID: 27935845
Structural, thermodynamic and catalytic characterization of an ancestral triosephosphate isomerase reveal early evolutionary coupling between monomer association and function.
Schulte-Sasse M, Pardo-Ávila F, Pulido-Mayoral NO, Vázquez-Lobo A, Costas M, García-Hernández E, Rodríguez-Romero A, Fernández-Velasco DA. Schulte-Sasse M, et al. Among authors: costas m. FEBS J. 2019 Mar;286(5):882-900. doi: 10.1111/febs.14741. Epub 2019 Jan 15. FEBS J. 2019. PMID: 30589511 Free article.
The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach.
Romero-Romero S, Costas M, Silva Manzano DA, Kordes S, Rojas-Ortega E, Tapia C, Guerra Y, Shanmugaratnam S, Rodríguez-Romero A, Baker D, Höcker B, Fernández-Velasco DA. Romero-Romero S, et al. Among authors: costas m. J Mol Biol. 2021 Sep 3;433(18):167153. doi: 10.1016/j.jmb.2021.167153. Epub 2021 Jul 14. J Mol Biol. 2021. PMID: 34271011 Free PMC article.
Thermodynamic and kinetic analysis of the LAO binding protein and its isolated domains reveal non-additivity in stability, folding and function.
Vergara R, Berrocal T, Juárez Mejía EI, Romero-Romero S, Velázquez-López I, Pulido NO, López Sanchez HA, Silva DA, Costas M, Rodríguez-Romero A, Rodríguez-Sotres R, Sosa-Peinado A, Fernández-Velasco DA. Vergara R, et al. Among authors: costas m. FEBS J. 2023 Sep;290(18):4496-4512. doi: 10.1111/febs.16819. Epub 2023 May 29. FEBS J. 2023. PMID: 37178351
407 results