Ruppel KM - Search Results

1

Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.

Ujfalusi Z, Vera CD, Mijailovich SM, Svicevic M, Yu EC, Kawana M, Ruppel KM, Spudich JA, Geeves MA, Leinwand LA. Ujfalusi Z, et al. Among authors: ruppel km. J Biol Chem. 2018 Jun 8;293(23):9017-9029. doi: 10.1074/jbc.RA118.001938. Epub 2018 Apr 17. J Biol Chem. 2018. PMID: 29666183 Free PMC article.

2

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function.

Sommese RF, Sung J, Nag S, Sutton S, Deacon JC, Choe E, Leinwand LA, Ruppel K, Spudich JA. Sommese RF, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12607-12. doi: 10.1073/pnas.1309493110. Epub 2013 Jun 24. Proc Natl Acad Sci U S A. 2013. PMID: 23798412 Free PMC article.

3

Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin.

Sommese RF, Nag S, Sutton S, Miller SM, Spudich JA, Ruppel KM. Sommese RF, et al. Among authors: ruppel km. PLoS One. 2013 Dec 18;8(12):e83403. doi: 10.1371/journal.pone.0083403. eCollection 2013. PLoS One. 2013. PMID: 24367593 Free PMC article.

4

Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.

Aksel T, Choe Yu E, Sutton S, Ruppel KM, Spudich JA. Aksel T, et al. Among authors: ruppel km. Cell Rep. 2015 May 12;11(6):910-920. doi: 10.1016/j.celrep.2015.04.006. Epub 2015 Apr 30. Cell Rep. 2015. PMID: 25937279 Free PMC article.

5

Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules.

Sung J, Nag S, Mortensen KI, Vestergaard CL, Sutton S, Ruppel K, Flyvbjerg H, Spudich JA. Sung J, et al. Nat Commun. 2015 Aug 4;6:7931. doi: 10.1038/ncomms8931. Nat Commun. 2015. PMID: 26239258 Free PMC article.

6

Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin.

Pan S, Sommese RF, Sallam KI, Nag S, Sutton S, Miller SM, Spudich JA, Ruppel KM, Ashley EA. Pan S, et al. Among authors: ruppel km. BMC Med Genet. 2015 Oct 26;16:97. doi: 10.1186/s12881-015-0243-5. BMC Med Genet. 2015. PMID: 26498512 Free PMC article.

7

Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.

Nag S, Sommese RF, Ujfalusi Z, Combs A, Langer S, Sutton S, Leinwand LA, Geeves MA, Ruppel KM, Spudich JA. Nag S, et al. Among authors: ruppel km. Sci Adv. 2015 Oct 9;1(9):e1500511. doi: 10.1126/sciadv.1500511. eCollection 2015 Oct. Sci Adv. 2015. PMID: 26601291 Free PMC article.

8

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin.

Spudich JA, Aksel T, Bartholomew SR, Nag S, Kawana M, Yu EC, Sarkar SS, Sung J, Sommese RF, Sutton S, Cho C, Adhikari AS, Taylor R, Liu C, Trivedi D, Ruppel KM. Spudich JA, et al. Among authors: ruppel km. J Exp Biol. 2016 Jan;219(Pt 2):161-7. doi: 10.1242/jeb.125930. J Exp Biol. 2016. PMID: 26792326 Free PMC article. Review.

9

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation.

Homburger JR, Green EM, Caleshu C, Sunitha MS, Taylor RE, Ruppel KM, Metpally RP, Colan SD, Michels M, Day SM, Olivotto I, Bustamante CD, Dewey FE, Ho CY, Spudich JA, Ashley EA. Homburger JR, et al. Among authors: ruppel km. Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6701-6. doi: 10.1073/pnas.1606950113. Epub 2016 May 31. Proc Natl Acad Sci U S A. 2016. PMID: 27247418 Free PMC article.

10

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin.

Adhikari AS, Kooiker KB, Sarkar SS, Liu C, Bernstein D, Spudich JA, Ruppel KM. Adhikari AS, et al. Among authors: ruppel km. Cell Rep. 2016 Dec 13;17(11):2857-2864. doi: 10.1016/j.celrep.2016.11.040. Cell Rep. 2016. PMID: 27974200 Free PMC article.

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