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Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells.
Chen GQ, Shi XG, Tang W, Xiong SM, Zhu J, Cai X, Han ZG, Ni JH, Shi GY, Jia PM, Liu MM, He KL, Niu C, Ma J, Zhang P, Zhang TD, Paul P, Naoe T, Kitamura K, Miller W, Waxman S, Wang ZY, de The H, Chen SJ, Chen Z. Chen GQ, et al. Among authors: de the h. Blood. 1997 May 1;89(9):3345-53. Blood. 1997. PMID: 9129041 Free article.
Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies.
Koken MH, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JH, Zhu J, Dong S, Chen S, Chen Z, Tan CC, Licht J, Waxman S, de Thé H, Zelent A. Koken MH, et al. Among authors: de the h. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10255-60. doi: 10.1073/pnas.94.19.10255. Proc Natl Acad Sci U S A. 1997. PMID: 9294197 Free PMC article.
PML induces a novel caspase-independent death process.
Quignon F, De Bels F, Koken M, Feunteun J, Ameisen JC, de Thé H. Quignon F, et al. Among authors: de the h, de bels f. Nat Genet. 1998 Nov;20(3):259-65. doi: 10.1038/3068. Nat Genet. 1998. PMID: 9806544
Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation.
Lallemand-Breitenbach V, Zhu J, Puvion F, Koken M, Honoré N, Doubeikovsky A, Duprez E, Pandolfi PP, Puvion E, Freemont P, de Thé H. Lallemand-Breitenbach V, et al. Among authors: de the h. J Exp Med. 2001 Jun 18;193(12):1361-71. doi: 10.1084/jem.193.12.1361. J Exp Med. 2001. PMID: 11413191 Free PMC article.
286 results