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High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches.
Eur J Pharm Sci. 2018 Jul 1;119:70-82. doi: 10.1016/j.ejps.2018.03.026. Epub 2018 Mar 26.
Eur J Pharm Sci. 2018.
PMID: 29592839
Amino acid adduct formation by the nevirapine metabolite, 12-hydroxynevirapine--a possible factor in nevirapine toxicity.
Antunes AM, Godinho AL, Martins IL, Justino GC, Beland FA, Marques MM.
Antunes AM, et al.
Chem Res Toxicol. 2010 May 17;23(5):888-99. doi: 10.1021/tx900443z.
Chem Res Toxicol. 2010.
PMID: 20392079
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Protein adducts as prospective biomarkers of nevirapine toxicity.
Antunes AM, Godinho AL, Martins IL, Oliveira MC, Gomes RA, Coelho AV, Beland FA, Marques MM.
Antunes AM, et al.
Chem Res Toxicol. 2010 Nov 15;23(11):1714-25. doi: 10.1021/tx100186t. Epub 2010 Sep 1.
Chem Res Toxicol. 2010.
PMID: 20809596
Free PMC article.
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Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity.
Charneira C, Godinho AL, Oliveira MC, Pereira SA, Monteiro EC, Marques MM, Antunes AM.
Charneira C, et al.
Chem Res Toxicol. 2011 Dec 19;24(12):2129-41. doi: 10.1021/tx200337b. Epub 2011 Nov 11.
Chem Res Toxicol. 2011.
PMID: 22032494
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Evidence for nevirapine bioactivation in man: searching for the first step in the mechanism of nevirapine toxicity.
Caixas U, Antunes AM, Marinho AT, Godinho AL, Grilo NM, Marques MM, Oliveira MC, Branco T, Monteiro EC, Pereira SA.
Caixas U, et al.
Toxicology. 2012 Nov 15;301(1-3):33-9. doi: 10.1016/j.tox.2012.06.013. Epub 2012 Jun 28.
Toxicology. 2012.
PMID: 22750752
Clinical Trial.
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N-terminal valine adduct from the anti-HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo.
Charneira C, Grilo NM, Pereira SA, Godinho AL, Monteiro EC, Marques MM, Antunes AM.
Charneira C, et al.
Br J Pharmacol. 2012 Nov;167(6):1353-61. doi: 10.1111/j.1476-5381.2012.02079.x.
Br J Pharmacol. 2012.
PMID: 22725138
Free PMC article.
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