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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Among authors: murphy mp. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.
Prime TA, Blaikie FH, Evans C, Nadtochiy SM, James AM, Dahm CC, Vitturi DA, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani ET, Hurd TR, Garvey JF, Taylor CT, Brookes PS, Smith RA, Murphy MP. Prime TA, et al. Among authors: murphy mp. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10764-9. doi: 10.1073/pnas.0903250106. Epub 2009 Jun 15. Proc Natl Acad Sci U S A. 2009. PMID: 19528654 Free PMC article.
Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation.
Chouchani ET, Hurd TR, Nadtochiy SM, Brookes PS, Fearnley IM, Lilley KS, Smith RA, Murphy MP. Chouchani ET, et al. Among authors: murphy mp. Biochem J. 2010 Aug 15;430(1):49-59. doi: 10.1042/BJ20100633. Biochem J. 2010. PMID: 20533907 Free PMC article.
Measuring mitochondrial protein thiol redox state.
Requejo R, Chouchani ET, Hurd TR, Menger KE, Hampton MB, Murphy MP. Requejo R, et al. Among authors: murphy mp. Methods Enzymol. 2010;474:123-47. doi: 10.1016/S0076-6879(10)74008-8. Epub 2010 Jun 20. Methods Enzymol. 2010. PMID: 20609908
Proteomic approaches to the characterization of protein thiol modification.
Chouchani ET, James AM, Fearnley IM, Lilley KS, Murphy MP. Chouchani ET, et al. Among authors: murphy mp. Curr Opin Chem Biol. 2011 Feb;15(1):120-8. doi: 10.1016/j.cbpa.2010.11.003. Epub 2010 Dec 2. Curr Opin Chem Biol. 2011. PMID: 21130020 Free PMC article. Review.
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.
Cochemé HM, Quin C, McQuaker SJ, Cabreiro F, Logan A, Prime TA, Abakumova I, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RA, Saeed S, Carré JE, Singer M, Gems D, Hartley RC, Partridge L, Murphy MP. Cochemé HM, et al. Among authors: murphy mp. Cell Metab. 2011 Mar 2;13(3):340-50. doi: 10.1016/j.cmet.2011.02.003. Cell Metab. 2011. PMID: 21356523 Free PMC article.
Mitochondria-targeted small molecule therapeutics and probes.
Smith RA, Hartley RC, Murphy MP. Smith RA, et al. Among authors: murphy mp. Antioxid Redox Signal. 2011 Dec 15;15(12):3021-38. doi: 10.1089/ars.2011.3969. Epub 2011 Jun 6. Antioxid Redox Signal. 2011. PMID: 21395490 Review.
794 results