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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Among authors: modis lk. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
Malonylation of GAPDH is an inflammatory signal in macrophages.
Galván-Peña S, Carroll RG, Newman C, Hinchy EC, Palsson-McDermott E, Robinson EK, Covarrubias S, Nadin A, James AM, Haneklaus M, Carpenter S, Kelly VP, Murphy MP, Modis LK, O'Neill LA. Galván-Peña S, et al. Among authors: modis lk. Nat Commun. 2019 Jan 18;10(1):338. doi: 10.1038/s41467-018-08187-6. Nat Commun. 2019. PMID: 30659183 Free PMC article.
Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages.
Jimenez-Duran G, Kozole J, Peltier-Heap R, Dickinson ER, Kwiatkowski CR, Zappacosta F, Annan RS, Galwey NW, Nichols EM, Modis LK, Triantafilou M, Triantafilou K, Booty LM. Jimenez-Duran G, et al. Among authors: modis lk. Front Immunol. 2022 Sep 27;13:918551. doi: 10.3389/fimmu.2022.918551. eCollection 2022. Front Immunol. 2022. PMID: 36248901 Free PMC article.
A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo.
Lewis ND, Patnaude LA, Pelletier J, Souza DJ, Lukas SM, King FJ, Hill JD, Stefanopoulos DE, Ryan K, Desai S, Skow D, Kauschke SG, Broermann A, Kuzmich D, Harcken C, Hickey ER, Modis LK. Lewis ND, et al. Among authors: modis lk. PLoS One. 2014 Jun 26;9(6):e100883. doi: 10.1371/journal.pone.0100883. eCollection 2014. PLoS One. 2014. PMID: 24967665 Free PMC article.
Differential recognition of HIV-stimulated IL-1β and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages.
Triantafilou K, Ward CJK, Czubala M, Ferris RG, Koppe E, Haffner C, Piguet V, Patel VK, Amrine-Madsen H, Modis LK, Masters SL, Triantafilou M. Triantafilou K, et al. Among authors: modis lk. PLoS Pathog. 2021 Apr 16;17(4):e1009417. doi: 10.1371/journal.ppat.1009417. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33861800 Free PMC article.
CCL17 in Inflammation and Pain.
Lee KM, Jarnicki A, Achuthan A, Fleetwood AJ, Anderson GP, Ellson C, Feeney M, Modis LK, Smith JE, Hamilton JA, Cook A. Lee KM, et al. Among authors: modis lk. J Immunol. 2020 Jul 1;205(1):213-222. doi: 10.4049/jimmunol.2000315. Epub 2020 May 27. J Immunol. 2020. PMID: 32461237
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