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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Among authors: hartley rc. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
A dual sensor spin trap for use with EPR spectroscopy.
Caldwell ST, Quin C, Edge R, Hartley RC. Caldwell ST, et al. Among authors: hartley rc. Org Lett. 2007 Aug 30;9(18):3499-502. doi: 10.1021/ol071285o. Epub 2007 Aug 1. Org Lett. 2007. PMID: 17665918
Bioavailability of [2-(14)C]quercetin-4'-glucoside in rats.
Mullen W, Rouanet JM, Auger C, Teissèdre PL, Caldwell ST, Hartley RC, Lean ME, Edwards CA, Crozier A. Mullen W, et al. Among authors: hartley rc. J Agric Food Chem. 2008 Dec 24;56(24):12127-37. doi: 10.1021/jf802754s. J Agric Food Chem. 2008. PMID: 19053221
Mitochondria-targeted small molecule therapeutics and probes.
Smith RA, Hartley RC, Murphy MP. Smith RA, et al. Among authors: hartley rc. Antioxid Redox Signal. 2011 Dec 15;15(12):3021-38. doi: 10.1089/ars.2011.3969. Epub 2011 Jun 6. Antioxid Redox Signal. 2011. PMID: 21395490 Review.
Mitochondrial pharmacology.
Smith RA, Hartley RC, Cochemé HM, Murphy MP. Smith RA, et al. Among authors: hartley rc. Trends Pharmacol Sci. 2012 Jun;33(6):341-52. doi: 10.1016/j.tips.2012.03.010. Epub 2012 Apr 18. Trends Pharmacol Sci. 2012. PMID: 22521106 Free article. Review.
101 results