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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Among authors: hams e. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
Transcription factor RORα is critical for nuocyte development.
Wong SH, Walker JA, Jolin HE, Drynan LF, Hams E, Camelo A, Barlow JL, Neill DR, Panova V, Koch U, Radtke F, Hardman CS, Hwang YY, Fallon PG, McKenzie AN. Wong SH, et al. Among authors: hams e. Nat Immunol. 2012 Jan 22;13(3):229-36. doi: 10.1038/ni.2208. Nat Immunol. 2012. PMID: 22267218 Free PMC article.
Innate type 2 cells and asthma.
Hams E, Fallon PG. Hams E, et al. Curr Opin Pharmacol. 2012 Aug;12(4):503-9. doi: 10.1016/j.coph.2012.06.001. Epub 2012 Jun 29. Curr Opin Pharmacol. 2012. PMID: 22749407 Review.
The schistosoma granuloma: friend or foe?
Hams E, Aviello G, Fallon PG. Hams E, et al. Front Immunol. 2013 Apr 15;4:89. doi: 10.3389/fimmu.2013.00089. eCollection 2013. Front Immunol. 2013. PMID: 23596444 Free PMC article.
46 results