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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.
Chowdhry S, Nazmy MH, Meakin PJ, Dinkova-Kostova AT, Walsh SV, Tsujita T, Dillon JF, Ashford ML, Hayes JD. Chowdhry S, et al. Free Radic Biol Med. 2010 Jan 15;48(2):357-71. doi: 10.1016/j.freeradbiomed.2009.11.007. Epub 2009 Nov 13. Free Radic Biol Med. 2010. PMID: 19914374
The cytoprotective role of the Keap1-Nrf2 pathway.
Baird L, Dinkova-Kostova AT. Baird L, et al. Arch Toxicol. 2011 Apr;85(4):241-72. doi: 10.1007/s00204-011-0674-5. Epub 2011 Mar 2. Arch Toxicol. 2011. PMID: 21365312 Review.
191 results