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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Among authors: brunori g. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis.
Selvarajah B, Azuelos I, Platé M, Guillotin D, Forty EJ, Contento G, Woodcock HV, Redding M, Taylor A, Brunori G, Durrenberger PF, Ronzoni R, Blanchard AD, Mercer PF, Anastasiou D, Chambers RC. Selvarajah B, et al. Among authors: brunori g. Sci Signal. 2019 May 21;12(582):eaav3048. doi: 10.1126/scisignal.aav3048. Sci Signal. 2019. PMID: 31113850 Free PMC article.
Endothelial cells in tumor microenvironment: insights and perspectives.
Leone P, Malerba E, Susca N, Favoino E, Perosa F, Brunori G, Prete M, Racanelli V. Leone P, et al. Among authors: brunori g. Front Immunol. 2024 Feb 15;15:1367875. doi: 10.3389/fimmu.2024.1367875. eCollection 2024. Front Immunol. 2024. PMID: 38426109 Free PMC article. Review.
The use of extracorporeal blood purification therapies and sequential extracorporeal support in patients with septic shock (EROICASS): a study protocol for a national, non-interventional, observational multicenter, prospective study.
De Rosa S, Ferrari F, Greco M, Pota V, Umbrello M, Cotoia A, Pasin L, Nalesso F, Paternoster G, Villa G, Lassola S, Miori S, Sanna A, Cantaluppi V, Marengo M, Valente F, Fiorentino M, Brunori G, Bellani G, Giarratano A. De Rosa S, et al. Among authors: brunori g. J Anesth Analg Crit Care. 2024 Feb 26;4(1):16. doi: 10.1186/s44158-024-00153-7. J Anesth Analg Crit Care. 2024. PMID: 38409062 Free PMC article.
Altered adiponectin regulation in skeletal muscle of patients with chronic kidney disease.
Verzola D, Saio M, Milanesi S, Picciotto D, Frascio M, Brunori G, Laudon A, La Porta E, Rumeo N, Zanetti V, Russo E, Garibotto G, Viazzi F, Esposito P. Verzola D, et al. Among authors: brunori g. Nephrol Dial Transplant. 2024 Feb 23:gfae051. doi: 10.1093/ndt/gfae051. Online ahead of print. Nephrol Dial Transplant. 2024. PMID: 38400552 No abstract available.
183 results