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Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies.
Slatter DA, Percy CL, Allen-Redpath K, Gajsiewicz JM, Brooks NJ, Clayton A, Tyrrell VJ, Rosas M, Lauder SN, Watson A, Dul M, Garcia-Diaz Y, Aldrovandi M, Heurich M, Hall J, Morrissey JH, Lacroix-Desmazes S, Delignat S, Jenkins PV, Collins PW, O'Donnell VB. Slatter DA, et al. JCI Insight. 2018 Mar 22;3(6):e98459. doi: 10.1172/jci.insight.98459. JCI Insight. 2018. PMID: 29563336 Free PMC article.
Quantitative assays for esterified oxylipins generated by immune cells.
Morgan AH, Hammond VJ, Morgan L, Thomas CP, Tallman KA, Garcia-Diaz YR, McGuigan C, Serpi M, Porter NA, Murphy RC, O'Donnell VB. Morgan AH, et al. Nat Protoc. 2010 Dec;5(12):1919-31. doi: 10.1038/nprot.2010.162. Epub 2010 Nov 10. Nat Protoc. 2010. PMID: 21127486 Free PMC article.
Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity.
Lauder SN, Taylor PR, Clark SR, Evans RL, Hindley JP, Smart K, Leach H, Kidd EJ, Broadley KJ, Jones SA, Wise MP, Godkin AJ, O'Donnell V, Gallimore AM. Lauder SN, et al. Thorax. 2011 May;66(5):368-74. doi: 10.1136/thx.2010.150318. Epub 2011 Feb 10. Thorax. 2011. PMID: 21310755 Free PMC article.
Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ.
Hammond VJ, Morgan AH, Lauder S, Thomas CP, Brown S, Freeman BA, Lloyd CM, Davies J, Bush A, Levonen AL, Kansanen E, Villacorta L, Chen YE, Porter N, Garcia-Diaz YM, Schopfer FJ, O'Donnell VB. Hammond VJ, et al. J Biol Chem. 2012 Dec 7;287(50):41651-66. doi: 10.1074/jbc.M112.405407. Epub 2012 Oct 11. J Biol Chem. 2012. PMID: 23060450 Free PMC article. Clinical Trial.
Oxidized PLs and vascular inflammation.
Aldrovandi M, O'Donnell VB. Aldrovandi M, et al. Curr Atheroscler Rep. 2013 May;15(5):323. doi: 10.1007/s11883-013-0323-y. Curr Atheroscler Rep. 2013. PMID: 23512607 Free PMC article. Review.
167 results