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Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen.
He Y, Chen Y, Mooney SM, Rajagopalan K, Bhargava A, Sacho E, Weninger K, Bryan PN, Kulkarni P, Orban J. He Y, et al. Among authors: orban j. J Biol Chem. 2015 Oct 9;290(41):25090-102. doi: 10.1074/jbc.M115.658583. Epub 2015 Aug 4. J Biol Chem. 2015. PMID: 26242913 Free PMC article.
Knocking down PAGE4 expression results in cell death, whereas its overexpression leads to a growth advantage of prostate cancer cells (Zeng, Y., He, Y., Yang, F., Mooney, S. M., Getzenberg, R. H., Orban, J., and Kulkarni, P. (2011) The cancer/testis antigen prostate …
Knocking down PAGE4 expression results in cell death, whereas its overexpression leads to a growth advantage of prostate cancer cells (Zeng, …
Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.
Kulkarni P, Jolly MK, Jia D, Mooney SM, Bhargava A, Kagohara LT, Chen Y, Hao P, He Y, Veltri RW, Grishaev A, Weninger K, Levine H, Orban J. Kulkarni P, et al. Among authors: orban j. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2644-E2653. doi: 10.1073/pnas.1700082114. Epub 2017 Mar 13. Proc Natl Acad Sci U S A. 2017. PMID: 28289210 Free PMC article.
Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level.
Lin X, Kulkarni P, Bocci F, Schafer NP, Roy S, Tsai MY, He Y, Chen Y, Rajagopalan K, Mooney SM, Zeng Y, Weninger K, Grishaev A, Onuchic JN, Levine H, Wolynes PG, Salgia R, Rangarajan G, Uversky V, Orban J, Jolly MK. Lin X, et al. Among authors: orban j. Biomolecules. 2019 Feb 22;9(2):77. doi: 10.3390/biom9020077. Biomolecules. 2019. PMID: 30813315 Free PMC article.
A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer.
Mohanty A, Nam A, Pozhitkov A, Yang L, Srivastava S, Nathan A, Wu X, Mambetsariev I, Nelson M, Subbalakshmi AR, Guo L, Nasser MW, Batra SK, Orban J, Jolly MK, Massarelli E, Kulkarni P, Salgia R. Mohanty A, et al. Among authors: orban j. iScience. 2020 Aug 22;23(9):101496. doi: 10.1016/j.isci.2020.101496. eCollection 2020 Sep 25. iScience. 2020. PMID: 32947124 Free PMC article.
197 results