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Orchestrated control of filaggrin-actin scaffolds underpins cornification.
Gutowska-Owsiak D, de La Serna JB, Fritzsche M, Naeem A, Podobas EI, Leeming M, Colin-York H, O'Shaughnessy R, Eggeling C, Ogg GS. Gutowska-Owsiak D, et al. Cell Death Dis. 2018 Apr 1;9(4):412. doi: 10.1038/s41419-018-0407-2. Cell Death Dis. 2018. PMID: 29545605 Free PMC article.
AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation.
O'Shaughnessy RF, Welti JC, Cooke JC, Avilion AA, Monks B, Birnbaum MJ, Byrne C. O'Shaughnessy RF, et al. J Biol Chem. 2007 Jun 8;282(23):17297-305. doi: 10.1074/jbc.M610386200. Epub 2007 Apr 17. J Biol Chem. 2007. PMID: 17439945 Free article.
A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis.
Naeem AS, Tommasi C, Cole C, Brown SJ, Zhu Y, Way B, Willis Owen SA, Moffatt M, Cookson WO, Harper JI, Di WL, Brown SJ, Reinheckel T, O'Shaughnessy RF. Naeem AS, et al. J Allergy Clin Immunol. 2017 Apr;139(4):1228-1241. doi: 10.1016/j.jaci.2016.09.052. Epub 2016 Nov 29. J Allergy Clin Immunol. 2017. PMID: 27913303 Free PMC article.
175 results