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Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.
Szpakowska M, Meyrath M, Reynders N, Counson M, Hanson J, Steyaert J, Chevigné A. Szpakowska M, et al. Among authors: steyaert j. Biochem Pharmacol. 2018 Jul;153:299-309. doi: 10.1016/j.bcp.2018.03.007. Epub 2018 Mar 9. Biochem Pharmacol. 2018. PMID: 29530506
Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody.
Sohier JS, Laurent C, Chevigné A, Pardon E, Srinivasan V, Wernery U, Lassaux P, Steyaert J, Galleni M. Sohier JS, et al. Among authors: steyaert j. Biochem J. 2013 Mar 15;450(3):477-86. doi: 10.1042/BJ20121305. Biochem J. 2013. PMID: 23289540 Free article.
Propagation of conformational changes during μ-opioid receptor activation.
Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S. Sounier R, et al. Among authors: steyaert j. Nature. 2015 Aug 20;524(7565):375-8. doi: 10.1038/nature14680. Epub 2015 Aug 5. Nature. 2015. PMID: 26245377 Free PMC article.
Structural insights into µ-opioid receptor activation.
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Huang W, et al. Among authors: steyaert j. Nature. 2015 Aug 20;524(7565):315-21. doi: 10.1038/nature14886. Epub 2015 Aug 5. Nature. 2015. PMID: 26245379 Free PMC article.
Nanobodies to Study G Protein-Coupled Receptor Structure and Function.
Manglik A, Kobilka BK, Steyaert J. Manglik A, et al. Among authors: steyaert j. Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:19-37. doi: 10.1146/annurev-pharmtox-010716-104710. Epub 2016 Dec 7. Annu Rev Pharmacol Toxicol. 2017. PMID: 27959623 Free PMC article. Review.
Structural basis for GABAA receptor potentiation by neurosteroids.
Miller PS, Scott S, Masiulis S, De Colibus L, Pardon E, Steyaert J, Aricescu AR. Miller PS, et al. Among authors: steyaert j. Nat Struct Mol Biol. 2017 Nov;24(11):986-992. doi: 10.1038/nsmb.3484. Epub 2017 Oct 9. Nat Struct Mol Biol. 2017. PMID: 28991263 Free PMC article.
425 results