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A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment.
Shen J, Najafi S, Stäble S, Fabian J, Koeneke E, Kolbinger FR, Wrobel JK, Meder B, Distel M, Heimburg T, Sippl W, Jung M, Peterziel H, Kranz D, Boutros M, Westermann F, Witt O, Oehme I. Shen J, et al. Among authors: boutros m. Cell Death Differ. 2018 Dec;25(12):2053-2070. doi: 10.1038/s41418-018-0080-0. Epub 2018 Mar 7. Cell Death Differ. 2018. PMID: 29515255 Free PMC article.
RNAi screening in cultured Drosophila cells.
Steinbrink S, Boutros M. Steinbrink S, et al. Among authors: boutros m. Methods Mol Biol. 2008;420:139-53. doi: 10.1007/978-1-59745-583-1_8. Methods Mol Biol. 2008. PMID: 18641945
Microscopy-Based High-Content Screening.
Boutros M, Heigwer F, Laufer C. Boutros M, et al. Cell. 2015 Dec 3;163(6):1314-25. doi: 10.1016/j.cell.2015.11.007. Cell. 2015. PMID: 26638068 Free article. Review.
Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
Voloshanenko O, Gmach P, Winter J, Kranz D, Boutros M. Voloshanenko O, et al. Among authors: boutros m. FASEB J. 2017 Nov;31(11):4832-4844. doi: 10.1096/fj.201700144R. Epub 2017 Jul 21. FASEB J. 2017. PMID: 28733458 Free PMC article.
Together, our results map functional interactions of FZDs and 10 Wnt ligands and demonstrate how multiplex targeting by clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 can be used to systematically elucidate the functions of multigene families.-Voloshanenko …
Together, our results map functional interactions of FZDs and 10 Wnt ligands and demonstrate how multiplex targeting by clustered regularly …
ERAD-dependent control of the Wnt secretory factor Evi.
Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M. Glaeser K, et al. Among authors: boutros m. EMBO J. 2018 Feb 15;37(4):e97311. doi: 10.15252/embj.201797311. Epub 2018 Jan 29. EMBO J. 2018. PMID: 29378775 Free PMC article.
Targeting euchromatic histone lysine methyltransferases sensitizes colorectal cancer to histone deacetylase inhibitors.
Bamberg LV, Heigwer F, Wandmacher AM, Singh A, Betge J, Rindtorff N, Werner J, Josten J, Skabkina OV, Hinsenkamp I, Erdmann G, Röcken C, Ebert MP, Burgermeister E, Zhan T, Boutros M. Bamberg LV, et al. Among authors: boutros m. Int J Cancer. 2022 Nov 1;151(9):1586-1601. doi: 10.1002/ijc.34155. Epub 2022 Jun 28. Int J Cancer. 2022. PMID: 35666536 Free article.
384 results