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Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.
Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R. Mitchell SJ, et al. Among authors: di francesco a. Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001. Cell Metab. 2018. PMID: 29514072 Free PMC article.
Disulfiram Treatment Normalizes Body Weight in Obese Mice.
Bernier M, Mitchell SJ, Wahl D, Diaz A, Singh A, Seo W, Wang M, Ali A, Kaiser T, Price NL, Aon MA, Kim EY, Petr MA, Cai H, Warren A, Di Germanio C, Di Francesco A, Fishbein K, Guiterrez V, Harney D, Koay YC, Mach J, Enamorado IN, Pulpitel T, Wang Y, Zhang J, Zhang L, Spencer RG, Becker KG, Egan JM, Lakatta EG, O'Sullivan J, Larance M, LeCouteur DG, Cogger VC, Gao B, Fernandez-Hernando C, Cuervo AM, de Cabo R. Bernier M, et al. Among authors: di francesco a, di germanio c. Cell Metab. 2020 Aug 4;32(2):203-214.e4. doi: 10.1016/j.cmet.2020.04.019. Epub 2020 May 14. Cell Metab. 2020. PMID: 32413333 Free PMC article.
Two-Year Trial of Human Caloric Restriction.
Di Francesco A, de Cabo R. Di Francesco A, et al. J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1095-6. doi: 10.1093/gerona/glv100. Epub 2015 Jul 17. J Gerontol A Biol Sci Med Sci. 2015. PMID: 26187232 No abstract available.
Intermittent mTOR Inhibition Reverses Kidney Aging in Old Rats.
Di Francesco A, Diaz-Ruiz A, de Cabo R, Bernier M. Di Francesco A, et al. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):843-844. doi: 10.1093/gerona/gly023. J Gerontol A Biol Sci Med Sci. 2018. PMID: 29420687 Free PMC article. No abstract available.
Yo-Yo Dieting is Better than None.
Di Germanio C, Di Francesco A, Bernier M, de Cabo R. Di Germanio C, et al. Among authors: di francesco a. Obesity (Silver Spring). 2018 Nov;26(11):1673. doi: 10.1002/oby.22335. Obesity (Silver Spring). 2018. PMID: 30358152 Free PMC article.
A time to fast.
Di Francesco A, Di Germanio C, Bernier M, de Cabo R. Di Francesco A, et al. Among authors: di germanio c. Science. 2018 Nov 16;362(6416):770-775. doi: 10.1126/science.aau2095. Science. 2018. PMID: 30442801 Free PMC article. Review.
NQO1 protects obese mice through improvements in glucose and lipid metabolism.
Di Francesco A, Choi Y, Bernier M, Zhang Y, Diaz-Ruiz A, Aon MA, Kalafut K, Ehrlich MR, Murt K, Ali A, Pearson KJ, Levan S, Preston JD, Martin-Montalvo A, Martindale JL, Abdelmohsen K, Michel CR, Willmes DM, Henke C, Navas P, Villalba JM, Siegel D, Gorospe M, Fritz K, Biswal S, Ross D, de Cabo R. Di Francesco A, et al. NPJ Aging Mech Dis. 2020 Nov 19;6(1):13. doi: 10.1038/s41514-020-00051-6. NPJ Aging Mech Dis. 2020. PMID: 33298924 Free PMC article.
Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.
Di Francesco A, Di Germanio C, Panda AC, Huynh P, Peaden R, Navas-Enamorado I, Bastian P, Lehrmann E, Diaz-Ruiz A, Ross D, Siegel D, Martindale JL, Bernier M, Gorospe M, Abdelmohsen K, de Cabo R. Di Francesco A, et al. Among authors: di germanio c. Free Radic Biol Med. 2016 Oct;99:225-233. doi: 10.1016/j.freeradbiomed.2016.08.005. Epub 2016 Aug 8. Free Radic Biol Med. 2016. PMID: 27515817 Free PMC article.
Overexpression of CYB5R3 and NQO1, two NAD+ -producing enzymes, mimics aspects of caloric restriction.
Diaz-Ruiz A, Lanasa M, Garcia J, Mora H, Fan F, Martin-Montalvo A, Di Francesco A, Calvo-Rubio M, Salvador-Pascual A, Aon MA, Fishbein KW, Pearson KJ, Villalba JM, Navas P, Bernier M, de Cabo R. Diaz-Ruiz A, et al. Among authors: di francesco a. Aging Cell. 2018 Aug;17(4):e12767. doi: 10.1111/acel.12767. Epub 2018 Apr 28. Aging Cell. 2018. PMID: 29706024 Free PMC article.
369 results