Trésaugues L - Search Results

1

Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.

Rahm F, Viklund J, Trésaugues L, Ellermann M, Giese A, Ericsson U, Forsblom R, Ginman T, Günther J, Hallberg K, Lindström J, Persson LB, Silvander C, Talagas A, Díaz-Sáez L, Fedorov O, Huber KVM, Panagakou I, Siejka P, Gorjánácz M, Bauser M, Andersson M. Rahm F, et al. Among authors: tresaugues l. J Med Chem. 2018 Mar 22;61(6):2533-2551. doi: 10.1021/acs.jmedchem.7b01884. Epub 2018 Mar 7. J Med Chem. 2018. PMID: 29485874

2

Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.

Ellermann M, Eheim A, Rahm F, Viklund J, Guenther J, Andersson M, Ericsson U, Forsblom R, Ginman T, Lindström J, Silvander C, Trésaugues L, Giese A, Bunse S, Neuhaus R, Weiske J, Quanz M, Glasauer A, Nowak-Reppel K, Bader B, Irlbacher H, Meyer H, Queisser N, Bauser M, Haegebarth A, Gorjánácz M. Ellermann M, et al. Among authors: tresaugues l. ACS Chem Biol. 2017 Aug 18;12(8):1986-1992. doi: 10.1021/acschembio.7b00370. Epub 2017 Jul 12. ACS Chem Biol. 2017. PMID: 28679043 Free article.

3

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.

Mills SJ, Silvander C, Cozier G, Trésaugues L, Nordlund P, Potter BV. Mills SJ, et al. Among authors: tresaugues l. Biochemistry. 2016 Mar 8;55(9):1384-97. doi: 10.1021/acs.biochem.5b00838. Epub 2016 Feb 29. Biochemistry. 2016. PMID: 26854536 Free PMC article.

4

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.

Trésaugues L, Silvander C, Flodin S, Welin M, Nyman T, Gräslund S, Hammarström M, Berglund H, Nordlund P. Trésaugues L, et al. Structure. 2014 May 6;22(5):744-55. doi: 10.1016/j.str.2014.01.013. Epub 2014 Apr 3. Structure. 2014. PMID: 24704254 Free article.

5

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.

Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, Gräslund S, Nordlund P. Trésaugues L, et al. PLoS One. 2015 Jun 29;10(6):e0131507. doi: 10.1371/journal.pone.0131507. eCollection 2015. PLoS One. 2015. PMID: 26121039 Free PMC article.

6

Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.

Thorsell AG, Ekblad T, Karlberg T, Löw M, Pinto AF, Trésaugues L, Moche M, Cohen MS, Schüler H. Thorsell AG, et al. Among authors: tresaugues l. J Med Chem. 2017 Feb 23;60(4):1262-1271. doi: 10.1021/acs.jmedchem.6b00990. Epub 2016 Dec 21. J Med Chem. 2017. PMID: 28001384 Free PMC article.

7

Correction to "Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors".

Thorsell AG, Ekblad T, Karlberg T, Löw M, Pinto AF, Trésaugues L, Moche M, Cohen MS, Schüler H. Thorsell AG, et al. Among authors: tresaugues l. J Med Chem. 2019 Jun 27;62(12):5922. doi: 10.1021/acs.jmedchem.9b00852. Epub 2019 Jun 19. J Med Chem. 2019. PMID: 31242737 No abstract available.

8

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site.

Trésaugues L, Stenmark P, Schüler H, Flodin S, Welin M, Nyman T, Hammarström M, Moche M, Gräslund S, Nordlund P. Trésaugues L, et al. Proteins. 2008 Dec;73(4):1047-52. doi: 10.1002/prot.22198. Proteins. 2008. PMID: 18767156 No abstract available.

9

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.

Herman MD, Nyman T, Welin M, Lehtiö L, Flodin S, Trésaugues L, Kotenyova T, Flores A, Nordlund P. Herman MD, et al. Among authors: tresaugues l. FEBS Lett. 2008 Oct 29;582(25-26):3590-4. doi: 10.1016/j.febslet.2008.09.028. Epub 2008 Sep 21. FEBS Lett. 2008. PMID: 18812174 Free article.

10

Structures of BIR domains from human NAIP and cIAP2.

Herman MD, Moche M, Flodin S, Welin M, Trésaugues L, Johansson I, Nilsson M, Nordlund P, Nyman T. Herman MD, et al. Among authors: tresaugues l. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Nov 1;65(Pt 11):1091-6. doi: 10.1107/S1744309109038597. Epub 2009 Oct 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009. PMID: 19923725 Free PMC article.

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