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Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
J Med Chem. 2018 Mar 22;61(6):2533-2551. doi: 10.1021/acs.jmedchem.7b01884. Epub 2018 Mar 7.
J Med Chem. 2018.
PMID: 29485874
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
Ellermann M, Eheim A, Rahm F, Viklund J, Guenther J, Andersson M, Ericsson U, Forsblom R, Ginman T, Lindström J, Silvander C, Trésaugues L, Giese A, Bunse S, Neuhaus R, Weiske J, Quanz M, Glasauer A, Nowak-Reppel K, Bader B, Irlbacher H, Meyer H, Queisser N, Bauser M, Haegebarth A, Gorjánácz M.
Ellermann M, et al. Among authors: silvander c.
ACS Chem Biol. 2017 Aug 18;12(8):1986-1992. doi: 10.1021/acschembio.7b00370. Epub 2017 Jul 12.
ACS Chem Biol. 2017.
PMID: 28679043
Free article.
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Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Mills SJ, Silvander C, Cozier G, Trésaugues L, Nordlund P, Potter BV.
Mills SJ, et al. Among authors: silvander c.
Biochemistry. 2016 Mar 8;55(9):1384-97. doi: 10.1021/acs.biochem.5b00838. Epub 2016 Feb 29.
Biochemistry. 2016.
PMID: 26854536
Free PMC article.
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Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.
Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, Gräslund S, Nordlund P.
Trésaugues L, et al. Among authors: silvander c.
PLoS One. 2015 Jun 29;10(6):e0131507. doi: 10.1371/journal.pone.0131507. eCollection 2015.
PLoS One. 2015.
PMID: 26121039
Free PMC article.
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Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.
Trésaugues L, Silvander C, Flodin S, Welin M, Nyman T, Gräslund S, Hammarström M, Berglund H, Nordlund P.
Trésaugues L, et al. Among authors: silvander c.
Structure. 2014 May 6;22(5):744-55. doi: 10.1016/j.str.2014.01.013. Epub 2014 Apr 3.
Structure. 2014.
PMID: 24704254
Free article.
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Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.
Yu Y, Bogdan M, Noman MZ, Parpal S, Bartolini E, Van Moer K, Kleinendorst SC, Bilgrav Saether K, Trésaugues L, Silvander C, Lindström J, Simeon J, Timson MJ, Al-Hashimi H, Smith BD, Flynn DL, Alexeyenko A, Viklund J, Andersson M, Martinsson J, Pokrovskaja Tamm K, De Milito A, Janji B.
Yu Y, et al. Among authors: silvander c.
Mol Oncol. 2024 Mar 20. doi: 10.1002/1878-0261.13619. Online ahead of print.
Mol Oncol. 2024.
PMID: 38506049
Free article.
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Very high cell density perfusion of CHO cells anchored in a non-woven matrix-based bioreactor.
Zhang Y, Stobbe P, Silvander CO, Chotteau V.
Zhang Y, et al. Among authors: silvander co.
J Biotechnol. 2015 Nov 10;213:28-41. doi: 10.1016/j.jbiotec.2015.07.006. Epub 2015 Jul 23.
J Biotechnol. 2015.
PMID: 26211737
Free article.
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