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Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
J Med Chem. 2018 Mar 22;61(6):2533-2551. doi: 10.1021/acs.jmedchem.7b01884. Epub 2018 Mar 7.
J Med Chem. 2018.
PMID: 29485874
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
Ellermann M, Eheim A, Rahm F, Viklund J, Guenther J, Andersson M, Ericsson U, Forsblom R, Ginman T, Lindström J, Silvander C, Trésaugues L, Giese A, Bunse S, Neuhaus R, Weiske J, Quanz M, Glasauer A, Nowak-Reppel K, Bader B, Irlbacher H, Meyer H, Queisser N, Bauser M, Haegebarth A, Gorjánácz M.
Ellermann M, et al. Among authors: ginman t.
ACS Chem Biol. 2017 Aug 18;12(8):1986-1992. doi: 10.1021/acschembio.7b00370. Epub 2017 Jul 12.
ACS Chem Biol. 2017.
PMID: 28679043
Free article.
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Core refinement toward permeable β-secretase (BACE-1) inhibitors with low hERG activity.
Ginman T, Viklund J, Malmström J, Blid J, Emond R, Forsblom R, Johansson A, Kers A, Lake F, Sehgelmeble F, Sterky KJ, Bergh M, Lindgren A, Johansson P, Jeppsson F, Fälting J, Gravenfors Y, Rahm F.
Ginman T, et al.
J Med Chem. 2013 Jun 13;56(11):4181-205. doi: 10.1021/jm3011349. Epub 2013 May 20.
J Med Chem. 2013.
PMID: 23126626
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New aminoimidazoles as β-secretase (BACE-1) inhibitors showing amyloid-β (Aβ) lowering in brain.
Gravenfors Y, Viklund J, Blid J, Ginman T, Karlström S, Kihlström J, Kolmodin K, Lindström J, von Berg S, von Kieseritzky F, Bogar K, Slivo C, Swahn BM, Olsson LL, Johansson P, Eketjäll S, Fälting J, Jeppsson F, Strömberg K, Janson J, Rahm F.
Gravenfors Y, et al. Among authors: ginman t.
J Med Chem. 2012 Nov 8;55(21):9297-311. doi: 10.1021/jm300991n. Epub 2012 Oct 3.
J Med Chem. 2012.
PMID: 23017051
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Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship.
Macsari I, Sandberg L, Besidski Y, Gravenfors Y, Ginman T, Bylund J, Bueters T, Eriksson AB, Lund PE, Venyike E, Arvidsson PI.
Macsari I, et al. Among authors: ginman t.
Bioorg Med Chem Lett. 2011 Jul 1;21(13):3871-6. doi: 10.1016/j.bmcl.2011.05.041. Epub 2011 May 18.
Bioorg Med Chem Lett. 2011.
PMID: 21641215
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Rapid and Robust Quantification of p-Xyleneselenocyanate in Plasma via Derivatization.
Zheng W, Benkessou F, Twelkmeyer B, Wang S, Ginman T, Ottosson H, Abedi-Valugerdi M, Subirana MA, Zhao Y, Hassan M.
Zheng W, et al. Among authors: ginman t.
Anal Chem. 2017 Jul 18;89(14):7586-7592. doi: 10.1021/acs.analchem.7b01426. Epub 2017 Jul 5.
Anal Chem. 2017.
PMID: 28640579
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Pharmacokinetic profile of N-acetylcysteine amide and its main metabolite in mice using new analytical method.
He R, Zheng W, Ginman T, Ottosson H, Norgren S, Zhao Y, Hassan M.
He R, et al. Among authors: ginman t.
Eur J Pharm Sci. 2020 Feb 15;143:105158. doi: 10.1016/j.ejps.2019.105158. Epub 2019 Nov 16.
Eur J Pharm Sci. 2020.
PMID: 31740394
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A general covalent binding model between cytotoxic selenocompounds and albumin revealed by mass spectrometry and X-ray absorption spectroscopy.
Zheng W, He R, Boada R, Subirana MA, Ginman T, Ottosson H, Valiente M, Zhao Y, Hassan M.
Zheng W, et al. Among authors: ginman t.
Sci Rep. 2020 Jan 27;10(1):1274. doi: 10.1038/s41598-020-57983-y.
Sci Rep. 2020.
PMID: 31988319
Free PMC article.
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