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Backbone Cyclization Turns a Venom Peptide into a Stable and Equipotent Ligand at Both Muscle and Neuronal Nicotinic Receptors.
Giribaldi J, Haufe Y, Evans ERJ, Amar M, Durner A, Schmidt C, Faucherre A, Moha Ou Maati H, Enjalbal C, Molgó J, Servent D, Wilson DT, Daly NL, Nicke A, Dutertre S. Giribaldi J, et al. Among authors: amar m. J Med Chem. 2020 Nov 12;63(21):12682-12692. doi: 10.1021/acs.jmedchem.0c00957. Epub 2020 Oct 16. J Med Chem. 2020. PMID: 33063995
The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK.
Boëx M, Cottin S, Halliez M, Bauché S, Buon C, Sans N, Montcouquiol M, Molgó J, Amar M, Ferry A, Lemaitre M, Rouche A, Langui D, Baskaran A, Fontaine B, Messéant J, Strochlic L. Boëx M, et al. Among authors: amar m. Sci Signal. 2022 May 17;15(734):eabg4982. doi: 10.1126/scisignal.abg4982. Epub 2022 May 17. Sci Signal. 2022. PMID: 35580169
426 results