Kolb P - Search Results

1

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors.

Pardon E, Betti C, Laeremans T, Chevillard F, Guillemyn K, Kolb P, Ballet S, Steyaert J. Pardon E, et al. Among authors: kolb p. Angew Chem Int Ed Engl. 2018 May 4;57(19):5292-5295. doi: 10.1002/anie.201712581. Epub 2018 Mar 30. Angew Chem Int Ed Engl. 2018. PMID: 29469969

2

The golden age of GPCR structural biology: any impact on drug design?

Kolb P, Klebe G. Kolb P, et al. Angew Chem Int Ed Engl. 2011 Dec 2;50(49):11573-5. doi: 10.1002/anie.201105869. Epub 2011 Nov 3. Angew Chem Int Ed Engl. 2011. PMID: 22052652 No abstract available.

3

Structure of active coagulation factor XIII triggered by calcium binding: basis for the design of next-generation anticoagulants.

Stieler M, Weber J, Hils M, Kolb P, Heine A, Büchold C, Pasternack R, Klebe G. Stieler M, et al. Among authors: kolb p. Angew Chem Int Ed Engl. 2013 Nov 4;52(45):11930-4. doi: 10.1002/anie.201305133. Epub 2013 Sep 20. Angew Chem Int Ed Engl. 2013. PMID: 24115223 No abstract available.

4

SCUBIDOO: A Large yet Screenable and Easily Searchable Database of Computationally Created Chemical Compounds Optimized toward High Likelihood of Synthetic Tractability.

Chevillard F, Kolb P. Chevillard F, et al. Among authors: kolb p. J Chem Inf Model. 2015 Sep 28;55(9):1824-35. doi: 10.1021/acs.jcim.5b00203. Epub 2015 Sep 4. J Chem Inf Model. 2015. PMID: 26282054

5

Binding-Site Compatible Fragment Growing Applied to the Design of β₂-Adrenergic Receptor Ligands.

Chevillard F, Rimmer H, Betti C, Pardon E, Ballet S, van Hilten N, Steyaert J, Diederich WE, Kolb P. Chevillard F, et al. Among authors: kolb p. J Med Chem. 2018 Feb 8;61(3):1118-1129. doi: 10.1021/acs.jmedchem.7b01558. Epub 2018 Jan 24. J Med Chem. 2018. PMID: 29364664

6

Virtual Compound Libraries in Computer-Assisted Drug Discovery.

van Hilten N, Chevillard F, Kolb P. van Hilten N, et al. Among authors: kolb p. J Chem Inf Model. 2019 Feb 25;59(2):644-651. doi: 10.1021/acs.jcim.8b00737. Epub 2019 Jan 24. J Chem Inf Model. 2019. PMID: 30624918

7

Interrogating dense ligand chemical space with a forward-synthetic library.

Chevillard F, Stotani S, Karawajczyk A, Hristeva S, Pardon E, Steyaert J, Tzalis D, Kolb P. Chevillard F, et al. Among authors: kolb p. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11496-11501. doi: 10.1073/pnas.1818718116. Epub 2019 May 21. Proc Natl Acad Sci U S A. 2019. PMID: 31113876 Free PMC article.

8

Comparative Docking to Distinct G Protein-Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy.

Scharf MM, Bünemann M, Baker JG, Kolb P. Scharf MM, et al. Among authors: kolb p. Mol Pharmacol. 2019 Dec;96(6):851-861. doi: 10.1124/mol.119.117515. Epub 2019 Oct 17. Mol Pharmacol. 2019. PMID: 31624135

9

Fragment evolution for GPCRs: the role of secondary binding sites in optimization.

Chevillard F, Kelemen Á, Baker JG, Aranyodi VA, Balzer F, Kolb P, Keserű GM. Chevillard F, et al. Among authors: kolb p. Chem Commun (Camb). 2021 Oct 12;57(81):10516-10519. doi: 10.1039/d1cc04636e. Chem Commun (Camb). 2021. PMID: 34550124

10

Allosteric modulation of GPCRs: From structural insights to in silico drug discovery.

Persechino M, Hedderich JB, Kolb P, Hilger D. Persechino M, et al. Among authors: kolb p. Pharmacol Ther. 2022 Sep;237:108242. doi: 10.1016/j.pharmthera.2022.108242. Epub 2022 Jul 18. Pharmacol Ther. 2022. PMID: 35863587 Review.

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