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Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies.
Mayrhofer JE, Enzler F, Feichtner A, Röck R, Fleischmann J, Raffeiner A, Tschaikner P, Ogris E, Huber RG, Hartl M, Schneider R, Troppmair J, Torres-Quesada O, Stefan E. Mayrhofer JE, et al. Among authors: troppmair j. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31105-31113. doi: 10.1073/pnas.2012150117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229534 Free PMC article.
Isolation of a novel thioflavin S-derived compound that inhibits BAG-1-mediated protein interactions and targets BRAF inhibitor-resistant cell lines.
Enthammer M, Papadakis ES, Salomé Gachet M, Deutsch M, Schwaiger S, Koziel K, Ashraf MI, Khalid S, Wolber G, Packham G, Cutress RI, Stuppner H, Troppmair J. Enthammer M, et al. Among authors: troppmair j. Mol Cancer Ther. 2013 Nov;12(11):2400-14. doi: 10.1158/1535-7163.MCT-13-0142. Epub 2013 Sep 18. Mol Cancer Ther. 2013. PMID: 24048738
Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer.
Cato L, Neeb A, Sharp A, Buzón V, Ficarro SB, Yang L, Muhle-Goll C, Kuznik NC, Riisnaes R, Nava Rodrigues D, Armant O, Gourain V, Adelmant G, Ntim EA, Westerling T, Dolling D, Rescigno P, Figueiredo I, Fauser F, Wu J, Rottenberg JT, Shatkina L, Ester C, Luy B, Puchta H, Troppmair J, Jung N, Bräse S, Strähle U, Marto JA, Nienhaus GU, Al-Lazikani B, Salvatella X, de Bono JS, Cato AC, Brown M. Cato L, et al. Among authors: troppmair j. Elife. 2017 Aug 10;6:e27159. doi: 10.7554/eLife.27159. Elife. 2017. PMID: 28826504 Free PMC article.
Bilirubin inhibits tumor cell growth via activation of ERK.
Ollinger R, Kogler P, Troppmair J, Hermann M, Wurm M, Drasche A, Königsrainer I, Amberger A, Weiss H, Ofner D, Bach FH, Margreiter R. Ollinger R, et al. Among authors: troppmair j. Cell Cycle. 2007 Dec 15;6(24):3078-85. doi: 10.4161/cc.6.24.5022. Epub 2007 Sep 7. Cell Cycle. 2007. PMID: 18073533
160 results