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From RORγt Agonist to Two Types of RORγt Inverse Agonists.
Wang Y, Cai W, Tang T, Liu Q, Yang T, Yang L, Ma Y, Zhang G, Huang Y, Song X, Orband-Miller LA, Wu Q, Zhou L, Xiang Z, Xiang JN, Leung S, Shao L, Lin X, Lobera M, Ren F. Wang Y, et al. Among authors: huang y. ACS Med Chem Lett. 2018 Jan 22;9(2):120-124. doi: 10.1021/acsmedchemlett.7b00476. eCollection 2018 Feb 8. ACS Med Chem Lett. 2018. PMID: 29456799 Free PMC article.
Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors.
Wang Y, Cai W, Cheng Y, Yang T, Liu Q, Zhang G, Meng Q, Han F, Huang Y, Zhou L, Xiang Z, Zhao YG, Xu Y, Cheng Z, Lu S, Wu Q, Xiang JN, Elliott JD, Leung S, Ren F, Lin X. Wang Y, et al. Among authors: huang y. ACS Med Chem Lett. 2015 May 26;6(7):787-92. doi: 10.1021/acsmedchemlett.5b00122. eCollection 2015 Jul 9. ACS Med Chem Lett. 2015. PMID: 26191367 Free PMC article.
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with "short" and "long" inverse agonists.
Yu MC, Yang F, Ding XY, Sun NN, Jiang ZY, Huang YF, Yan YR, Zhu C, Xie Q, Chen ZF, Guo SQ, Jiang HL, Chen KX, Luo C, Luo XM, Chen SJ, Wang YH. Yu MC, et al. Acta Pharmacol Sin. 2021 Sep;42(9):1524-1534. doi: 10.1038/s41401-020-00552-w. Epub 2020 Nov 25. Acta Pharmacol Sin. 2021. PMID: 33239687 Free PMC article.
Discovery of tert-amine-based RORγt agonists.
Qiu R, Yu M, Gong J, Tian J, Huang Y, Wang Y, Xie Q. Qiu R, et al. Among authors: huang y. Eur J Med Chem. 2021 Nov 15;224:113704. doi: 10.1016/j.ejmech.2021.113704. Epub 2021 Jul 14. Eur J Med Chem. 2021. PMID: 34303081
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