Manoharan M - Search Results

1

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates.

Foster DJ, Brown CR, Shaikh S, Trapp C, Schlegel MK, Qian K, Sehgal A, Rajeev KG, Jadhav V, Manoharan M, Kuchimanchi S, Maier MA, Milstein S. Foster DJ, et al. Among authors: manoharan m. Mol Ther. 2018 Mar 7;26(3):708-717. doi: 10.1016/j.ymthe.2017.12.021. Epub 2018 Jan 4. Mol Ther. 2018. PMID: 29456020 Free PMC article.

2

Synthesis of chimeric oligonucleotides containing phosphodiester, phosphorothioate, and phosphoramidate linkages.

Maier MA, Guzaev AP, Manoharan M. Maier MA, et al. Among authors: manoharan m. Org Lett. 2000 Jun 29;2(13):1819-22. doi: 10.1021/ol005842h. Org Lett. 2000. PMID: 10891166

3

Synthesis of novel 3'-C-methylene thymidine and 5-methyluridine/cytidine H-phosphonates and phosphonamidites for new backbone modification of oligonucleotides.

An H, Wang T, Maier MA, Manoharan M, Ross BS, Cook PD. An H, et al. Among authors: manoharan m. J Org Chem. 2001 Apr 20;66(8):2789-801. doi: 10.1021/jo001699u. J Org Chem. 2001. PMID: 11304203

4

Nuclease resistance of oligonucleotides containing the tricyclic cytosine analogues phenoxazine and 9-(2-aminoethoxy)-phenoxazine ("G-clamp") and origins of their nuclease resistance properties.

Maier MA, Leeds JM, Balow G, Springer RH, Bharadwaj R, Manoharan M. Maier MA, et al. Among authors: manoharan m. Biochemistry. 2002 Jan 29;41(4):1323-7. doi: 10.1021/bi011725y. Biochemistry. 2002. PMID: 11802733

5

Systemically delivered antisense oligomers upregulate gene expression in mouse tissues.

Sazani P, Gemignani F, Kang SH, Maier MA, Manoharan M, Persmark M, Bortner D, Kole R. Sazani P, et al. Among authors: manoharan m. Nat Biotechnol. 2002 Dec;20(12):1228-33. doi: 10.1038/nbt759. Epub 2002 Nov 11. Nat Biotechnol. 2002. PMID: 12426578

6

High-affinity peptide nucleic acid oligomers containing tricyclic cytosine analogues.

Rajeev KG, Maier MA, Lesnik EA, Manoharan M. Rajeev KG, et al. Among authors: manoharan m. Org Lett. 2002 Dec 12;4(25):4395-8. doi: 10.1021/ol027026a. Org Lett. 2002. PMID: 12465896

7

Synthesis of antisense oligonucleotides conjugated to a multivalent carbohydrate cluster for cellular targeting.

Maier MA, Yannopoulos CG, Mohamed N, Roland A, Fritz H, Mohan V, Just G, Manoharan M. Maier MA, et al. Among authors: manoharan m. Bioconjug Chem. 2003 Jan-Feb;14(1):18-29. doi: 10.1021/bc020028v. Bioconjug Chem. 2003. PMID: 12526688

8

2'-modified-2-thiothymidine oligonucleotides.

Rajeev KG, Prakash TP, Manoharan M. Rajeev KG, et al. Among authors: manoharan m. Org Lett. 2003 Aug 21;5(17):3005-8. doi: 10.1021/ol0348607. Org Lett. 2003. PMID: 12916967

9

RNA interference and chemically modified siRNAs.

Manoharan M. Manoharan M. Nucleic Acids Res Suppl. 2003;(3):115-6. doi: 10.1093/nass/3.1.115. Nucleic Acids Res Suppl. 2003. PMID: 14510407

10

Synthesis and characterization of oligonucleotides containing conformationally constrained bicyclo[3.1.0]hexane pseudosugar analogs.

Maier MA, Choi Y, Gaus H, Barchi JJ Jr, Marquez VE, Manoharan M. Maier MA, et al. Among authors: manoharan m. Nucleic Acids Res. 2004 Jul 9;32(12):3642-50. doi: 10.1093/nar/gkh667. Print 2004. Nucleic Acids Res. 2004. PMID: 15247346 Free PMC article.

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