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A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
Rempel E, Hoelting L, Waldmann T, Balmer NV, Schildknecht S, Grinberg M, Das Gaspar JA, Shinde V, Stöber R, Marchan R, van Thriel C, Liebing J, Meisig J, Blüthgen N, Sachinidis A, Rahnenführer J, Hengstler JG, Leist M. Rempel E, et al. Among authors: hoelting l. Arch Toxicol. 2015 Sep;89(9):1599-618. doi: 10.1007/s00204-015-1573-y. Epub 2015 Aug 14. Arch Toxicol. 2015. PMID: 26272509 Free PMC article.
Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests.
Shinde V, Hoelting L, Srinivasan SP, Meisig J, Meganathan K, Jagtap S, Grinberg M, Liebing J, Bluethgen N, Rahnenführer J, Rempel E, Stoeber R, Schildknecht S, Förster S, Godoy P, van Thriel C, Gaspar JA, Hescheler J, Waldmann T, Hengstler JG, Leist M, Sachinidis A. Shinde V, et al. Among authors: hoelting l. Arch Toxicol. 2017 Feb;91(2):839-864. doi: 10.1007/s00204-016-1741-8. Epub 2016 May 17. Arch Toxicol. 2017. PMID: 27188386 Free PMC article.
Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants.
Hirsch C, Striegl B, Mathes S, Adlhart C, Edelmann M, Bono E, Gaan S, Salmeia KA, Hoelting L, Krebs A, Nyffeler J, Pape R, Bürkle A, Leist M, Wick P, Schildknecht S. Hirsch C, et al. Among authors: hoelting l. Arch Toxicol. 2017 Jan;91(1):407-425. doi: 10.1007/s00204-016-1680-4. Epub 2016 Feb 29. Arch Toxicol. 2017. PMID: 26928308 Free PMC article.
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.
Alépée N, Bahinski A, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H, Hoelting L, Kelm JM, Kadereit S, McVey E, Landsiedel R, Leist M, Lübberstedt M, Noor F, Pellevoisin C, Petersohn D, Pfannenbecker U, Reisinger K, Ramirez T, Rothen-Rutishauser B, Schäfer-Korting M, Zeilinger K, Zurich MG. Alépée N, et al. Among authors: hoelting l. ALTEX. 2014;31(4):441-77. doi: 10.14573/altex.1406111. Epub 2014 Jul 14. ALTEX. 2014. PMID: 25027500 Free PMC article. Review.