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Page 1
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors.
Hajji N, Garcia-Revilla J, Soto MS, Perryman R, Symington J, Quarles CC, Healey DR, Guo Y, Orta-Vázquez ML, Mateos-Cordero S, Shah K, Bomalaski J, Anichini G, Tzakos AG, Crook T, O'Neill K, Scheck AC, Venero JL, Syed N. Hajji N, et al. J Clin Invest. 2022 Mar 15;132(6):e142137. doi: 10.1172/JCI142137. J Clin Invest. 2022. PMID: 35113813 Free PMC article.
Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM.
Przystal JM, Hajji N, Khozoie C, Renziehausen A, Zeng Q, Abaitua F, Hajitou A, Suwan K, Want E, Bomalaski J, Szlosarek P, O'Neill K, Crook T, Syed N. Przystal JM, et al. Cell Death Dis. 2018 Dec 13;9(12):1192. doi: 10.1038/s41419-018-1195-4. Cell Death Dis. 2018. PMID: 30546006 Free PMC article.
A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma.
Hall PE, Lewis R, Syed N, Shaffer R, Evanson J, Ellis S, Williams M, Feng X, Johnston A, Thomson JA, Harris FP, Jena R, Matys T, Jefferies S, Smith K, Wu BW, Bomalaski JS, Crook T, O'Neill K, Paraskevopoulos D, Khadeir RS, Sheaff M, Pacey S, Plowman PN, Szlosarek PW. Hall PE, et al. Clin Cancer Res. 2019 May 1;25(9):2708-2716. doi: 10.1158/1078-0432.CCR-18-3729. Epub 2019 Feb 22. Clin Cancer Res. 2019. PMID: 30796035 Clinical Trial.
Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma.
Perryman R, Renziehausen A, Shaye H, Kostagianni AD, Tsiailanis AD, Thorne T, Chatziathanasiadou MV, Sivolapenko GB, El Mubarak MA, Han GW, Zarzycka B, Katritch V, Lebon G, Lo Nigro C, Lattanzio L, Morse SV, Choi JJ, O'Neill K, Kanaki Z, Klinakis A, Crook T, Cherezov V, Tzakos AG, Syed N. Perryman R, et al. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2116289119. doi: 10.1073/pnas.2116289119. Epub 2022 Aug 2. Proc Natl Acad Sci U S A. 2022. PMID: 35917342 Free PMC article.
The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a novel target for therapeutic intervention.
Renziehausen A, Wang H, Rao B, Weir L, Nigro CL, Lattanzio L, Merlano M, Vega-Rioja A, Del Carmen Fernandez-Carranco M, Hajji N, Matin R, Harwood C, Li S, Sim VR, O'Neill K, Evans A, Thompson A, Szlosarek P, Fleming C, Stebbing J, Proby C, Tzakos AG, Syed N, Crook T. Renziehausen A, et al. Oncogene. 2019 Mar;38(13):2320-2336. doi: 10.1038/s41388-018-0563-y. Epub 2018 Nov 26. Oncogene. 2019. PMID: 30478450 Free article.
Integrated systems-genetic analyses reveal a network target for delaying glioma progression.
Laaniste L, Srivastava PK, Stylianou J, Syed N, Cases-Cunillera S, Shkura K, Zeng Q, Rackham OJL, Langley SR, Delahaye-Duriez A, O'Neill K, Williams M, Becker A, Roncaroli F, Petretto E, Johnson MR. Laaniste L, et al. Ann Clin Transl Neurol. 2019 Sep;6(9):1616-1638. doi: 10.1002/acn3.50850. Epub 2019 Aug 17. Ann Clin Transl Neurol. 2019. PMID: 31420939 Free PMC article.
804 results