Methionine oxidized apolipoprotein A-I at the crossroads of HDL biogenesis and amyloid formation.
Witkowski A, Chan GKL, Boatz JC, Li NJ, Inoue AP, Wong JC, van der Wel PCA, Cavigiolio G.
Witkowski A, et al.
FASEB J. 2018 Jun;32(6):3149-3165. doi: 10.1096/fj.201701127R. Epub 2018 Jan 17.
FASEB J. 2018.
PMID: 29401604
Free PMC article.
Apolipoprotein A-I (apoA-I) shares with other exchangeable apolipoproteins a high level of structural plasticity. ...Our results suggest that even partial Met oxidation of apoA-I can nucleate amyloidogenesis, thus sequestering and inactivating otherwise antiatheroge …
Apolipoprotein A-I (apoA-I) shares with other exchangeable apolipoproteins a high level of structural plasticity. ...Our resul …