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Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.
Liu W, Zi M, Naumann R, Ulm S, Jin J, Taglieri DM, Prehar S, Gui J, Tsui H, Xiao RP, Neyses L, Solaro RJ, Ke Y, Cartwright EJ, Lei M, Wang X. Liu W, et al. Among authors: tsui h. Circulation. 2011 Dec 13;124(24):2702-15. doi: 10.1161/CIRCULATIONAHA.111.048785. Epub 2011 Nov 14. Circulation. 2011. PMID: 22082674 Free PMC article.
Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention.
Chowdhury SK, Liu W, Zi M, Li Y, Wang S, Tsui H, Prehar S, Castro S, Zhang H, Ji Y, Zhang X, Xiao R, Zhang R, Lei M, Cyganek L, Guan K, Millar CB, Liao X, Jain MK, Boyett MR, Cartwright EJ, Shiels HA, Wang X. Chowdhury SK, et al. Among authors: tsui h. Circulation. 2017 Feb 14;135(7):683-699. doi: 10.1161/CIRCULATIONAHA.116.022941. Epub 2016 Nov 29. Circulation. 2017. PMID: 27899394
A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin.
Liu W, Zi M, Tsui H, Chowdhury SK, Zeef L, Meng QJ, Travis M, Prehar S, Berry A, Hanley NA, Neyses L, Xiao RP, Oceandy D, Ke Y, Solaro RJ, Cartwright EJ, Lei M, Wang X. Liu W, et al. Among authors: tsui h. Circ Heart Fail. 2013 Jul;6(4):833-44. doi: 10.1161/CIRCHEARTFAILURE.112.000123. Epub 2013 Jun 10. Circ Heart Fail. 2013. PMID: 23753531 Free PMC article.
Pak1 is required to maintain ventricular Ca²⁺ homeostasis and electrophysiological stability through SERCA2a regulation in mice.
Wang Y, Tsui H, Ke Y, Shi Y, Li Y, Davies L, Cartwright EJ, Venetucci L, Zhang H, Terrar DA, Huang CL, Solaro RJ, Wang X, Lei M. Wang Y, et al. Among authors: tsui h. Circ Arrhythm Electrophysiol. 2014 Oct;7(5):938-48. doi: 10.1161/CIRCEP.113.001198. Epub 2014 Sep 12. Circ Arrhythm Electrophysiol. 2014. PMID: 25217043 Free PMC article.
Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age.
Davies L, Jin J, Shen W, Tsui H, Shi Y, Wang Y, Zhang Y, Hao G, Wu J, Chen S, Fraser JA, Dong N, Christoffels V, Ravens U, Huang CL, Zhang H, Cartwright EJ, Wang X, Lei M. Davies L, et al. Among authors: tsui h. J Am Heart Assoc. 2014 Apr 10;3(2):e000340. doi: 10.1161/JAHA.113.000340. J Am Heart Assoc. 2014. PMID: 24721794 Free PMC article.
387 results